DNA repair genes in endometriosis

Rükset Attar, Attar R, R Attar, Canan Cacına, C Cacina, Cacina C, S Sozen, Seval Sözen, Sozen S, Erkut Attar, Attar E, E Attar, B Agachan, Agachan B, Bedia Ağaçhan
Genetics and molecular research : GMR · 2010 · vol. 9(2) , pp. 629–636 · doi:10.4238/vol9-2gmr779 · PMID:20391347 · W1988329942
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This study investigated DNA repair gene polymorphisms and found that the XRCC3 Thr/Thr genotype was significantly more frequent in endometriosis patients compared to controls.

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Abstract

Several polymorphisms in the DNA repair gene are thought to have significant effects on cancer risk. We investigated the association of polymorphisms in the DNA repair genes XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys with endometriosis risk. Genotypes were determined by PCR-RFLP assays in 52 patients with endometriosis and 101 age-matched healthy controls. Although there were no significant (P > 0.05) differences in the frequencies of genotypes or alleles of APE1, XRCC1, XPD, XPG, and HOGG1 genes between patients and controls, the frequency of the XRCC3 Thr/Thr genotype was significantly greater in endometriosis patients compared with controls (P = 0.005). XRCC3 Thr/Met genotypes (P = 0.022), and the Met allele (P = 0.005) seem to have a protective role against endometriosis. The distributions of genotypes and alleles of the genes APE1, XRCC1, XRCC3, XPD, XPG, and HOGG1 were not significantly associated with the different stages of endometriosis (P > 0.05). We conclude that the XRCC3 Thr/Thr genotype is associated with endometriosis in Turkish women.

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Condition tags

endometriosis

MeSH descriptors

DNA Repair Endometriosis Adult Case-Control Studies DNA Repair Endometriosis Female Gene Frequency Gene Frequency Genotype Humans

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