GSTM1 and GSTT1 polymorphisms in endometriosis in women from Goiás, Brazil

A B Frare, Ariane Bocaletto Frare, A M Barbosa, Iasmim Ribeiro da Costa, I R Costa, S R Souza, R C P C Silva, B M Bordin, C L Ribeiro Júnior, K K V O Moura
Genetics and molecular research : GMR · 2013 · vol. 12(3) , pp. 2764–2770 · doi:10.4238/2013.august.2.1 · PMID:23979901 · W2146258064
article OA: bronze CC0 ⤵ 9 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated GSTM1 and GSTT1 gene polymorphisms in women with endometriosis from Goiás, Brazil, finding a higher frequency of gene absence but no statistically significant association with endometriosis proliferation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is a gynecologic pathology with a high prevalence and unknown etiology. Therefore, an increasing number of studies has been undertaken to search for associations between endometriosis and alterations or polymorphisms in candidate genes, including glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1). We analyzed the frequency of present/absent polymorphisms of GSTM1 and GSTT1 in 50 women diagnosed with endometriosis and in a control group of 46 women without complaints related to this pathology. The association of these polymorphisms with p53 gene codon 72 was also evaluated within each group, and a higher frequency of absence of GSTM1 (61%) and GSTT1 (45%) genes in the group of women studied, women with endometriosis and control group was found. The contributions of GSTM1 and GSTT1 polymorphisms to the proliferation of endometriosis were not statistically significant, but the analysis of pathology and the association of GSTM1 and GSTT1 gene polymorphisms with p53 codon 72 revealed statistical significance.

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Glutathione Transferase Polymorphism, Single Nucleotide Adult Brazil Case-Control Studies Endometriosis Female Genetic Association Studies Glutathione Transferase Humans Tumor Suppressor Protein p53 Tumor Suppressor Protein p53

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (17)

Cited by (9)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:18:53.335890+00:00
License: CC0 · commercial use OK