The codon 72 polymorphism of the TP53 gene and endometriosis risk: a meta-analysis

Feng Y, Yi Feng, Yuan-Yuan Wu, Yuanyuan Wu, Li Li, Li L, Zhijuan Luo, Luo ZJ, Zhi-Juan Luo, Lin Zhong, Zhong Lin, Lin Z, Zhou YH, Ying-Hui Zhou, Yinghui Zhou, Tao Yi, Yi T, Lin XJ, Xiaojuan Lin, Xiao-Juan Lin, Qian-Ying Zhao, Zhao QY, Qianying Zhao, Xia Zhao, Zhao X
Reproductive BioMedicine Online · 2015 · vol. 31(3) , pp. 320–326 · doi:10.1016/j.rbmo.2015.05.017 · PMID:26194887 · W1651535901
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This meta-analysis investigated the association between the TP53 codon 72 polymorphism and endometriosis risk, finding a potential link.

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Abstract

Endometriosis is a chronic, inflammatory and common gynaecological disease. This study investigated the association between TP53 codon 72 polymorphism and the risk of endometriosis. A search for relevant articles was conducted in PubMed, Embase, CNKI, Wanfang, Weipu databases and Google Scholar. The strength of the relationships between TP53 codon 72 polymorphism and the risk of endometriosis was assessed by odds ratios (OR) and with 95% confidence intervals (CI). Sixteen case-control studies in 15 articles were included. Significant association was found in the dominant model (CC + GC versus GG) with an OR of 1.38 and 95% CI (1.14, 1.67). The results suggested that individuals who carried CC homozygote and heterozygote GC might have a 38% increased endometriosis risk when compared with the homozygote GG. In the subgroup analysis by ethnicity, significantly increased risk was observed among Asians (OR = 1.62, 95% CI = 1.18-2.23, P = 0.003) and Latin Americans (OR = 1.54, 95% CI = 1.16-2.03, P = 0.002) but not in Caucasians (OR = 1.02, 95% CI = 0.80-1.30) for the dominant model. The current meta-analysis suggested that TP53 codon 72 polymorphism was associated with the endometriosis risk, especially in Asians and Latin Americans.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Polymorphism, Single Nucleotide Tumor Suppressor Protein p53 Endometriosis Female Humans Tumor Suppressor Protein p53

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (59)

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