RsaI polymorphism of the ERβgene in women with endometriosis

R C P C Silva, I R Costa, Iasmim Ribeiro da Costa, B M Bordin, C T X Silva, S R Souza, C L R Júnior, C.L. Ribeiro Júnior, Ariane Bocaletto Frare, A B Frare, K K V O Moura
Genetics and molecular research : GMR · 2011 · vol. 10(1) , pp. 465–470 · doi:10.4238/vol10-1gmr940 · PMID:21476192 · W2238176029
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that the heterozygous AG genotype of the RsaI polymorphism in the ERβ gene was significantly more frequent in women with endometriosis compared to controls.

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Abstract

We examined the frequency of RsaI polymorphism of the ERβ gene in 54 patients diagnosed with endometriosis and 46 controls. Peripheral blood was collected from women undergoing laparoscopy with a confirmed diagnosis of endometriosis. Polymorphisms of the ERβ gene and p53 were assessed by PCR and analyzed on 2% agarose gel stained with ethidium bromide. The AG polymorphism genotype frequency in patients with endometriosis was 59.3%, with 40.7% GG. In the control group, the frequency of AG was 6.5%, with 93.5% GG. The frequency of heterozygous AG was nine times higher in patients with endometriosis than in the control group (P < 0.0001).

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Deoxyribonucleases, Type II Site-Specific Endometriosis Estrogen Receptor beta Polymorphism, Genetic Adult Deoxyribonucleases, Type II Site-Specific Endometriosis Endometriosis Estrogen Receptor beta Estrogen Receptor beta Female Humans

Citation neighborhood

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References (17)

Cited by (15)

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