p21 gene codon 31 arginine/serine polymorphism: non-association with endometriosis

Y Y Hsieh, Yao‐Yuan Hsieh, Hsieh YY, Fuu‐Jen Tsai, F J Tsai, Tsai FJ, C C Chang, Chang CC, Chi‐Chen Chang, Chen WC, Wen‐Chi Chen, W C Chen, Tsai CH, C H Tsai, Chang‐Hai Tsai, Tsai HD, H D Tsai, Horng‐Der Tsai, C C Lin, Cheng‐Chieh Lin
Journal of clinical laboratory analysis · 2001 · vol. 15(4) , pp. 184–187 · doi:10.1002/jcla.1025 · PMID:11436200 · PMC6808162 · W2131419766
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This study investigated the p21 gene codon 31 arginine/serine polymorphism in relation to endometriosis and found no significant association between the polymorphism and the disease.

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Abstract

p21, an important regulator of the cell cycle, acts as a mediator of the growth-suppressing and -promoting functions of p53. We aimed to investigate the association between codon 31 polymorphisms of p21 gene and endometriosis. Women were divided into two groups: endometriosis (n = 102) and nonendometriosis (n = 119). The gene polymorphism for p21 codon 31 involved a base change from AGC to AGA and amino acid changes from serine (Ser) to arginine (Arg). Polymorphisms (Ser homozygotes, heterozygotes, Arg homozygotes) between both groups were detected and compared. Associations between the endometriosis and polymorphisms were evaluated. The results revealed that the distributions of different p21 polymorphisms in both groups were nonsignificantly different. The proportions of Ser homozygote/heterozygote/Arg homozygote in endometriosis and nonendometriois populations were 26.5/48.0/25.5% and 17.6/50.4/31.9%, respectively. We concluded the noncorrelation between the endometriosis and the p21 codon 31 polymorphism. p21 gene codon 31 arginine/serine polymorphism is not a useful marker for prediction of endometriosis susceptibility.

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Condition tags

endometriosis

MeSH descriptors

Arginine Cyclins Endometriosis Polymorphism, Genetic Polymorphism, Genetic Serine Arginine Arginine Codon Codon Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 Cyclins Cyclins Cyclins Endometriosis Endometriosis Female Female Heterozygote

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