Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis

Gabriela Meresman, G F Meresman, Susana Vighi, Vighi S, S Vighi, Buquet RA, R A Buquet, Ricardo Buquet, Contreras-Ortiz O, O Contreras-Ortiz, Oscar Contreras-Ortiz, M Tesone, Tesone M, Marta Tesone, Lía S. Rumi, Rumi LS, L S Rumi
Fertility and Sterility · 2000 · vol. 74(4) , pp. 760–766 · doi:10.1016/s0015-0282(00)01522-3 · PMID:11020520 · W2081717833
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This study investigated apoptosis and Bcl-2/Bax expression in eutopic endometrium from women with endometriosis.

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Abstract

ObjectiveTo evaluate and compare spontaneous apoptosis and Bcl-2 and Bax expression in eutopic endometrium from women with and without endometriosis.DesignApoptosis and Bcl-2 and Bax expression were examined in eutopic endometrium from women with and without endometriosis.SettingInstituto de Biología y Medicina Experimental-CONICET, Department of Gynecology and Department of Gynecological Pathology, Clínicas University Hospital, Buenos Aires, Argentina.Patient(s)Women with untreated endometriosis (n = 14) and controls (n = 16).Intervention(s)Collection of endometrial samples during diagnostic or therapeutic laparoscopy.Main outcome measure(s)Apoptotic cells were detected with use of the dUTP nick-end labeling (TUNEL) assay; Bcl-2 and Bax expressions were assessed with use of immunohistochemical techniques.Result(s)Spontaneous apoptosis was significantly lower in eutopic endometrium from patients with endometriosis, compared with healthy controls (2.26 +/- 0.53 and 9.37 +/- 1.69 apoptotic cells/field, respectively) and was independent of cycle phase. An increased expression of Bcl-2 protein was found in proliferative eutopic endometrium from patients with endometriosis. Bax expression was absent in proliferative endometrium, whereas there was an increase in its expression in secretory endometrium from both patients and controls.Conclusion(s)Women with endometriosis show decreased number of apoptotic cells in eutopic endometrium. The abnormal survival of endometrial cells may result in their continuing growth into ectopic locations.

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Condition tags

endometriosis

MeSH descriptors

Apoptosis Endometriosis Endometrium Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 bcl-2-Associated X Protein Endometriosis Endometrium Female Humans In Situ Hybridization Menstrual Cycle Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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