Effect of urolithins A and B on ectopic endometrial growth in a murine model of endometriosis

Bárbara Andrea Mc Cormack, Carla Noemí Olivares, Daniela Madanes, Analía Gabriela Ricci, Mariela Andrea Bilotas, Mariela Bilotas, Rosa Inés Barañao
Food & function · 2021 · vol. 12(20) , pp. 9894–9903 · doi:10.1039/d1fo01702k · PMID:34664592 · W3188102705
article OA: bronze CC0 ⤵ 3 in-corpus citations
🔓 Open OA copy Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

Urolithins A and B independently reduced ectopic endometrial growth in a murine endometriosis model without altering body weight or the estrous cycle.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

This study evaluated whether urolithins A and B alter the growth and survival of endometriotic-like lesions in a surgically induced endometriosis model using female BALB/C mice treated intraperitoneally with 2.5 mg kg−1 day−1 of either urolithin A or urolithin B for 28 days. The authors monitored estrous stage and body weight and then quantified lesions by counting and measuring after excision, alongside assessing epithelial and stromal proliferation and apoptosis in the implants. Urolithin A completely prevented endometriotic-like lesions, whereas urolithin B reduced implant volume, with both treatments lowering cellular proliferation and enhancing apoptosis. The paper’s main limitation is that the work is confined to a mouse model and does not establish clinical relevance for humans, though it is centrally about endometriosis—testing urolithins A and B as modulators of ectopic endometrial lesion growth and survival in endometriosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

< 0.01, respectively). These results are promising and reveal that urolithins A and B, separately, have a beneficial effect on the overall endometriotic growth without affecting the body weight or estrous cycle.
Full text 1,447 characters · extracted from oa-html · click to expand
Effect of urolithins A and B on ectopic endometrial growth in a murine model of endometriosis Abstract Endometriosis is an often painful disease in reproductive-aged women, in which endometrial-like tissue grows outside the uterine cavity. Since the limited current therapeutic alternatives fail in alleviating the symptoms and based on our previous research in in vitro models using the same compounds as the ones used in the present study, we aimed to evaluate the effects of urolithins A (UA) and B (UB) on the growth and survival of endometriotic-like lesions in a murine model of endometriosis. Female BALB/C mice were surgically induced with endometriosis and treated with 2.5 mg kg−1 day−1 intraperitoneal UA or UB. The mice were monitored daily and weighed and the estrous stage was determined. After 28 days of treatment, lesions were counted, measured, excised, and fixed. Both urolithins proved not to affect the estrous cycle or body weight of the mice. UA completely prevented endometriotic-like lesions, while UB diminished the implant volume (p < 0.05). Treatment also reduced epithelial and stromal cell proliferation within the implants (p < 0.001 and p < 0.01, respectively) and apoptosis was enhanced (p < 0.05 and p < 0.01, respectively). These results are promising and reveal that urolithins A and B, separately, have a beneficial effect on the overall endometriotic growth without affecting the body weight or estrous cycle.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

MeSH descriptors

Coumarins Endometriosis Animals Apoptosis Apoptosis Cell Proliferation Cell Proliferation Coumarins Disease Models, Animal Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Estrous Cycle Estrous Cycle Female Humans Mice

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (76)

Cited by (3)

Source provenance

europepmc
last seen: 2026-06-14T06:08:20.186862+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:24:14.728497+00:00
License: CC0 · commercial use OK