Early-stage endometriosis: adhesion and growth of human menstrual endometrium in nude mice
article
OA: bronze
CC0
⤵ 107 in-corpus citations
AI-generated summary
This study investigated the adhesion and growth of human menstrual endometrium in nude mice during early-stage endometriosis.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
ObjectiveTo evaluate the implantation of menstrual endometrium and the early stages of evolution of endometriotic lesions.DesignExperimental prospective study.SettingAn academic research environment.AnimalsTen nude mice.Intervention(s)A minilaparotomy was performed to place fresh human menstrual endometrial samples in the peritoneal cavity. Removal of the transplants was performed successively on days 1, 3, and 5 by laparotomy.Main outcome measure(s)Adhesion of endometrial fragments and early stages of endometrial lesions was morphologically and immunohistochemically studied.Result(s)As early as day 1, stromal cells were found to be attached to the mesothelium. A progressive reorganization of epithelial and stromal cells into endometrial glands was observed. On day 5, cystic endometriotic lesions were characterized by more extensive proliferative activity in glandular cells and a higher VEGF score in stromal cells than that observed in previously removed transplants.Conclusion(s)Menstrual human endometrium is able to implant on intact mesothelium and to reorganize itself into structured glands and stroma under the influence of unknown factors. We suggest that stromal and glandular cells have two distinct roles: stromal cells are involved in the attachment process and glandular cells in the growth of the endometriotic lesion.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (21)
- Adhesion of human endometrial fragments to peritoneum in vitro via openalex
- Adhesion of human endometrium to the epithelial lining and extracellular matrix of amnion in vitro: an electron microscopic study via openalex
- Adhesion of shed menstrual tissue in an in-vitro model using amnion and peritoneum: a light and electron microscopic study via openalex
- Dating the Endometrial Biopsy via openalex
- Effect of tumor necrosis factor-α on adhesion of human endometrial stromal cells to peritoneal mesothelial cells: an in vitro system via openalex
- Endometrial cell adhesion in an in vitro model using intact amniotic membranes via openalex
- Expression of integrins E-cadherin in cells from menstrual effluent, endometrium, peritoneal fluid, peritoneum, endometriosis via openalex
- Human endometrium transplanted into nude mice. Histologic effects of various steroid hormones. via openalex
- Immunohistochemical analysis of proliferative activity and steroid receptor expression in peritoneal and ovarian endometriosis via openalex
- Localization of laminin, fibronectin, E-cadherin, and integrins in endometrium and endometriosis via openalex
- Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex
- Successful heterotransplantation of human endometrium in SCID mice. via openalex
- Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. via openalex
- Transplantation of cultured explants of human endometrium into nude mice via openalex
- Transplantation of normal and ectopic human endometrial tissue into athymic nude mice via openalex
- Whole explants of peritoneum and endometrium: a novel model of the early endometriosis lesion via openalex
- W1506735060 via openalex
- W2140246703 via openalex
- W6713027323 via openalex
- W2090197643 via openalex
- W2077426616 via openalex
Cited by (50)
- Stilbene-based strategies for the management of endometriosis: targeting cell adhesion, migration, and ECM-driven invasion 2026
- Biomaterial Tools for Modeling Endometriosis 2026
- Spheroids as a model for endometriotic lesions 2023
- Forskolin versus cAMP-Induced Decidualization and Survival of Endometrial Stromal Cells of Endometriosis Patients 2023
- Endometrial stem/progenitor cells: Properties, origins, and functions 2022
- A novel nude mouse model for studying the pathogenesis of endometriosis 2022
- Endometriotic Organoids: A Novel In Vitro Model of Endometriotic Lesion Development 2022
- Unique Sensitivity of Uterine Tissue and the Immune System for Endometriotic Lesion Formation 2021
- Effect of urolithins A and B on ectopic endometrial growth in a murine model of endometriosis 2021
- The role of endometrial stem cells in the pathogenesis of endometriosis and their application to its early diagnosis† 2020
- Advanced oxidation protein products change biological behaviors of rats endometrial epithelial cells by activating ERK/P38 signaling pathways 2020
- CD44 variant 6 is involved in the attachment and invasion of endometrial cells to peritoneum 2020
- Fibrinogen alpha chain promotes the migration and invasion of human endometrial stromal cells in endometriosis through focal adhesion kinase/protein kinase B/matrix metallopeptidase 2 pathway† 2020
- TRIM59 inhibits PPM1A through ubiquitination and activates TGF-β/Smad signaling to promote the invasion of ectopic endometrial stromal cells in endometriosis 2020
- Rodent Models of Experimental Endometriosis: Identifying Mechanisms of Disease and Therapeutic Targets 2018
- Human chorionic gonadotropin induces decidualization of ectopic human endometrium more effectively than forskolin in an <i>in-vivo</i> endometriosis model 2018
- Active compounds present inRosmarinus officinalis leaves andScutellaria baicalensis root evaluated as new therapeutic agents for endometriosis 2018
- CLINICAL AND DEMOGRAPHIC FEATURES IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS 2017
- Decoy receptor 3 promotes cell adhesion and enhances endometriosis development 2017
- Experimental endometriosis models: different approaches for different tasks 2016
- Oral Administration of Pentoxifylline Reduces Endometriosis-Like Lesions in a Nude Mouse Model 2016
- Expression and significance of ERβ and TrkB in endometriosis 2016
- Laparoscopic Surgery: A New Technique to Induce Endometriosis in a Mouse Model 2016
- Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis 2016
- Animal Models in Endometriosis Research 2015
- Models of endometriosis and their utility in studying progression to ovarian clear cell carcinoma 2015
- Challenges in the development of novel therapeutic strategies for treatment of endometriosis 2015
- MODELS, BIOLOGICAL Development of a subcutaneous endometriosis rat model 1 2015
- Development of a subcutaneous endometriosis rat model 2015
- Contrast‐Enhanced Sonographic Features Before and After Interventional Treatment of Ovarian Endometrial Cysts 2015
- The effect of macrophages on fibroblast activity and lesion development in mouse models of endometriosis. 2014
- Die Wirkung von hCG auf die Dezidualisierung ektoper endometrialer Läsionen als therapeutischer Ansatz zur Behandlung der Endometriose 2014
- The Peritoneum Is Both a Source and Target of TGF-β in Women with Endometriosis 2014
- Menstrual endometrial supernatant may induce stromal endometriosis in baboons 2014
- Relation of peritoneal fluid and serum vascular endothelial growth factor levels to endometriosis stage 2014
- Endometrial Adult/Progenitor Stem Cells: Pathogenetic Theory and New Antiangiogenic Approach for Endometriosis Therapy 2013
- The role of the peritoneum in the pathogenesis of endometriosis 2013
- NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathways in the endometriotic milieu 2013
- Primate Model Research for Endometriosis 2012
- CXCL8 enhances proliferation and growth and reduces apoptosis in endometrial stromal cells in an autocrine manner via a CXCR1-triggered PTEN/AKT signal pathway 2012
- Novel Therapies Targeting Endometriosis 2011
- ROLE OF STROMAL CELL-DERIVED FACTOR-1 IN NEOANGIOGENESIS IN ENDOMETRIOSIS LESIONS 2011
- Inhibition of steroid sulfatase decreases endometriosis in an in vivo murine model 2011
- Peritoneal, Ovarian, and Rectovaginal Endometriosis are Three Different Entities 2011
- Models of Endometriosis: Animal Models I – Rodent‐Based Chimeric Models 2011
- Tumor Necrosis Factor-α and Interleukin-1β Treatment of Endometrial Stromal Cells Does not Promote Their Adhesion to Peritoneal Mesothelial Cells in an in Vitro Model of Early-Stage Endometriosis 2011
- Lymphatic Vessels in Peritoneal Endometriotic Lesions 2011
- The remedial effect of soluble interleukin-1 receptor type II on endometriosis in the nude mouse model 2010
- Involvement of the nuclear factor-kB pathway in the pathogenesis of endometriosis 2010
- The role of blood in early endometrial–peritoneal interactions in a syngeneic mouse model of endometriosis 2010
Source provenance
- europepmc
- last seen: 2026-07-28T06:14:09.330459+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:13:36.046895+00:00
License: CC0
· commercial use OK