Relation of peritoneal fluid and serum vascular endothelial growth factor levels to endometriosis stage

A Kopuz, Aycan Kopuz, Kopuz A, S Kurt, Kurt S, Sefa Kurt, Ö. Demirtaş Demirtaş, O Demirtas, Demirtas O, E Toz, Toz E, Emrah Töz, A. Taşyurt Taşyurt, A Tasyurt, Tasyurt A
Clinical and experimental obstetrics & gynecology · 2014 · vol. 41(5) , pp. 547–550 · doi:10.12891/ceog17422014 · PMID:25864257 · W2399174557
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-10 ⓘ

Serum vascular endothelial growth factor (VEGF) levels were significantly higher in patients with early stage (I and II) endometriosis compared to those with advanced stage (III and IV) or controls.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This study evaluated whether vascular endothelial growth factor (VEGF) levels in serum and peritoneal fluid are associated with the extent of endometriosis. Twenty-one women undergoing laparoscopic assessment for endometriosis (stages I–II vs III–IV) were compared with 19 women operated for extra-endometrial benign cysts, with simultaneous collection of peripheral blood and free peritoneal fluid from the Douglas pouch, followed by VEGF measurement using solid phase sandwich ELISA. The authors report that serum VEGF levels were statistically significantly higher in stage I–II endometriosis compared with stage III–IV and the control group, concluding there is a relationship between elevated serum VEGF and early-stage disease. This paper is centrally about endometriosis—specifically how peritoneal fluid and serum VEGF levels relate to endometriosis stage.

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Abstract

OBJECTIVE: It is a well known fact that endometriosis is linked with apoptosis, extracellular matrix formation, and angiogenesis. In this study, the authors aim to investigate the relation between the extent of endometriosis and vascular endothelial growth factor (VEGF). MATERIALS AND METHODS: Twenty-one patients who received laparoscopic intervention due to endometriosis constituted the patient group, whereas 19 patients who were operated due to extra-endometrial benign cyst were included in the control group. Following the laparoscopic pelvic assessment, peripheral blood samples and two cc of free peritoneal fluid from the Douglas pouch were obtained simultaneously. The samples were studied with regards to VEGF level via solid phase sandwich enzyme-linked immunosorbent assay (ELISA) method. RESULTS: In the patient group, eight cases were diagnosed with Stages I and II endometriosis, while 13 cases were diagnosed with Stages III and IV endometriosis. Among the Stage I and II cases, serum VEGF levels were statistically significantly higher, as compared to the Stage III and IV cases, as well as the control group. Discussion: In conclusion, the authors found a relationship between elevated serum VEGF levels and early stage endometriosis.
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Abstract

Objective: It is a well known fact that endometriosis is linked with apoptosis, extracellular matrix formation, and angiogenesis. In this study, the authors aim to investigate the relation between the extent of endometriosis and vascular endothelial growth factor (VEGF). Materials and Methods: Twenty-one patients who received laparoscopic intervention due to endometriosis constituted the patient group, whereas 19 patients who were operated due to extra-endometrial benign cyst were included in the control group. Following the laparoscopic pelvic assessment, peripheral blood samples and two cc of free peritoneal fluid from the Douglas pouch were obtained simultaneously. The samples were studied with regards to VEGF level via solid phase sandwich enzyme-linked immunosorbent assay (ELISA) method. Results: In the patient group, eight cases were diagnosed with Stages I and II endometriosis, while 13 cases were diagnosed with Stages III and IV endometriosis. Among the Stage I and II cases, serum VEGF levels were statistically significantly higher, as compared to the Stage III and IV cases, as well as the control group. Discussion: In conclusion, the authors found a relationship between elevated serum VEGF levels and early stage endometriosis.

Keywords

- Endometriosis - Vascular endothelial growth factor

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Uterine Diseases Vascular Endothelial Growth Factor A Adult Ascitic Fluid Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Humans Laparoscopy Middle Aged Retrospective Studies Severity of Illness Index Uterine Diseases Uterine Diseases Vascular Endothelial Growth Factor A Young Adult

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