Immunohistochemical analysis of vascular endothelial growth factor cellular expression in ovarian endometriomata
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This study analyzed the cellular expression of vascular endothelial growth factor (VEGF) in ovarian endometriomata using immunohistochemistry.
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Abstract
ObjectiveTo evaluate the expression of vascular endothelial growth factor (VEGF) in the cell populations of ovarian endometriomata cyst layers.DesignExperimental retrospective study.SettingUniversity hospital.Patient(s)Twenty-eight patients with ovarian endometriomata.Intervention(s)Surgical excision of 32 ovarian cysts.Main outcome measure(s)Histologic and VEGF immunohistochemical analysis of cyst layers.Result(s)Though the least represented cell types, macrophages exhibited the highest frequency of strong immunoreactivity, followed by capsular vessel endothelial and subepithelial stromal cells and by epithelial cells and capsular fibroblasts. Endothelia of the subepithelial stroma were the least immunoreactive cells. Diffuse VEGF expression in epithelial cells was associated with cyst diameters greater than 5.4 cm, and high VEGF expression in capsular fibroblasts was associated with bilateral cysts.Conclusion(s)Angiogenesis plays an active role in ovarian endometriosis, especially in the presence of large and bilateral cysts. Expression of VEGF in epithelial cells, capsular fibroblasts, and vessels was found to be related, suggesting that neoangiogenesis might especially affect the outer cyst wall, thus contributing to the fibrosing process of adhesion formation during cyst growth.
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Cited by (28)
- The roles and functions of macrophages in endometriosis 2021
- From Clinical Research to Clinical Practice in Obstetrics and Gynecology 2020
- Comparison of Menstrual Effluent Vascular Endothelial Growth Factor Immunocytochemistry Expression Between Endometriosis and Non-Endometriosis Patients 2020
- Basic mechanisms of vascularization in endometriosis and their clinical implications 2018
- Functional Expression of TRP Ion Channels in Endometrial Stromal Cells of Endometriosis Patients 2018
- A rare case of endometrioma in a bitch 2015
- Relation of peritoneal fluid and serum vascular endothelial growth factor levels to endometriosis stage 2014
- Inflammation and Cytokines in Endometriosis 2014
- Endometriosis, a disease of the macrophage 2013
- Endometriosis and Angiogenic Factors 2012
- “Spot”-ting differences between the ectopic and eutopic endometrium of endometriosis patients 2010
- Inhibitory effect of curcumin on angiogenesis in ectopic endometrium of rats with experimental endometriosis 2010
- Expression of Vascular Endothelial Growth Factor (VEGF), Hypoxia Inducible Factor-1α (HIF-1α), and Microvessel Density in Endometrial Tissue in Women With Adenomyosis 2009
- Interleukin-8 serum levels do not correlate with pelvic pain in patients with ovarian endometriomas 2009
- Thrombospondin-1 serum levels do not correlate with pelvic pain in patients with ovarian endometriosis 2009
- Endometriosis 2009
- Heterogeneous appearance of VEGF (vascular endothelial growth factor) immunopositivity in cyst capsules of endometrioma 2008
- Relationship between Microvascular Density and Expression of Vascular Endothelial Growth Factor in Patients with Ovarian Endometriosis 2008
- Expression of cyclooxygenase-2 and vascular endothelial growth factor in ovarian endometriotic cysts and their relationship with angiogenesis 2007
- Vascular endothelial growth factor (VEGF) and ovarian endometriosis: correlation between VEGF serum levels, VEGF cellular expression, and pelvic pain 2007
- Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum 2007
- Vascular endothelial growth factor and its soluble receptor in benign and malignant ovarian tumors 2007
- A baboon model for endometriosis: implications for fertility 2006
- A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis xenografts via antiangiogenic activity in severe combined immunodeficiency mice 2006
- Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis 2006
- Expression of an extracellular matrix metalloproteinase inducer (basigin) in the human ovary and ovarian endometriosis 2006
- Endothelial cell survivin is involved in the growth of ovarian endometriotic cysts. 2006
- Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions 2005
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