Endothelial cell survivin is involved in the growth of ovarian endometriotic cysts.

Gaia Goteri, Goteri G, Guendalina Lucarini, Lucarini G, Tiziana Pieramici, Pieramici T, Alessandra Filosa, Filosa A, Pugnaloni A, Armanda Pugnaloni, Nina Montik, Montik N, Graziella Biagini, Biagini G, G. Biagini, Andrea Luigi Tranquilli, Tranquilli AL, Guidalberto Fabris, Fabris G, Ciavattini A, Andrea Ciavattini, Lo Muzio L, Lorenzo Lo Muzio
Anticancer research · 2006 · vol. 25(6B) , pp. 4313–8 · PMID:16309234 · W2183926298
article OA: closed CC0 ⤵ 10 in-corpus citations
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Microvessel density in the fibrous capsule of ovarian endometriotic cysts, correlated with cyst diameter, is associated with endothelial cell expression of VEGF and survivin.

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Abstract

BACKGROUND: The aim of the present study was to evaluate microvessel density (MVD) in the cellular layers of ovarian endometriomata, with particular interest in the relationship with VEGF and survivin expressions by endothelial cells and with the diameter of the cysts. MATERIALS AND METHODS: MVD and VEGF and survivin endothelial cell expressions were evaluated in 26 ovarian endometriotic cysts and correlated with the cyst diameter. RESULTS: The mean MVD was higher in the inner specialized stroma of ectopic endometrium than in the outer fibrous capsule, but only in the fibrous capsule was MVD correlated with endothelial cell VEGF and survivin expressions as well as with the cyst diameter. CONCLUSION: The diameter of ovarian endometriotic cysts seems to be related to the angiogenic process involving the outer fibrous capsule, and not the inner specialized stroma of ectopic endometrium, since only in the capsule are vessels stimulated to proliferate by VEGF and protected from apoptosis by survivin, and their density is correlated to cyst diameter.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Microtubule-Associated Proteins Neoplasm Proteins Ovarian Cysts Ovarian Cysts Adult Cell Growth Processes Cell Growth Processes Endometriosis Endometriosis Endothelial Cells Endothelial Cells Endothelial Cells Female Humans Immunohistochemistry Inhibitor of Apoptosis Proteins Microtubule-Associated Proteins Neoplasm Proteins Ovarian Cysts

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