Survivin Gene Expression in Endometriosis

Ueda M, Masatsugu Ueda, Yamashita Y, Yoshiki Yamashita, Takehara M, Mikio Takehara, Terai Y, Yoshito Terai, Kumagai K, Koji Kumagai, Ken Ueki, Ueki K, Koji Kanda, Kanda K, Hiroyuki Yamaguchi, Yamaguchi H, Akise D, Daisuke Akise, Yao-Ching Hung, Yao‐Ching Hung, Hung YC, Ueki M, Minoru Ueki
The Journal of clinical endocrinology and metabolism · 2002 · vol. 87(7) , pp. 3452–3459 · doi:10.1210/jcem.87.7.8682 · PMID:12107265 · W2153717197
article OA: bronze CC0 ⤵ 55 in-corpus citations
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Survivin and MMP gene expression were significantly higher in aggressive endometriosis lesions than in normal endometrium, correlating with reduced apoptosis and increased invasion.

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Abstract

Survivin is a novel inhibitor of apoptosis and is expressed during fetal development and in cancer tissues, but its expression has not been reported in normal adult tissues or benign diseases. We investigated survivin gene and protein expression in a tumor-like benign disease, endometriosis, and correlated them with apoptosis and invasive phenotype of endometriotic tissues. Gene expression levels of survivin, matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1 (MT1)-MMP in 63 pigmented or nonpigmented endometriotic tissues surgically obtained from 35 women with endometriosis were compared with those in normal eutopic endometrium obtained from 12 women without endometriosis. Survivin, MMP-2, MMP-9, and MT1-MMP mRNA expression levels in clinically aggressive pigmented lesions were significantly higher than those in normal eutopic endometrium, and survivin gene expression in pigmented lesions was also higher than that in nonpigmented lesions (P < 0.05). There was a close correlation between survivin and MMP-2, MMP-9, or MT1-MMP gene expression levels in 63 endometriotic tissues examined (P < 0.01). Apoptotic cells detected by the dUTP nick-end labeling were rare in 11 ovarian endometriotic tissues, which showed positive immunohistochemical expression for survivin and MMPs. Our findings suggest that up-regulation of survivin and MMPs may cooperatively contribute to survival and invasion of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Chromosomal Proteins, Non-Histone Endometriosis Gene Expression Microtubule-Associated Proteins Adult Apoptosis Chromosomal Proteins, Non-Histone Chromosomal Proteins, Non-Histone Endometriosis Endometriosis Female Humans Inhibitor of Apoptosis Proteins Matrix Metalloproteinase 2 Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Matrix Metalloproteinase 9 Matrix Metalloproteinases, Membrane-Associated Metalloendopeptidases Metalloendopeptidases

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