Survivin gene expression in granulosa cells from infertile patients undergoing in vitro fertilization–embryo transfer

Fujino K, Kuniko Fujino, Yamashita Y, Yoshiki Yamashita, Atushi Hayashi, Hayashi A, Masako Asano, Asano M, Shoko Morishima, Morishima S, Ohmichi M, Masahide Ohmichi
Fertility and sterility · 2007 · vol. 89(1) , pp. 60–65 · doi:10.1016/j.fertnstert.2007.02.018 · PMID:17509581 · W1964332713
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Survivin gene expression was detected in granulosa cells from infertile patients, with lower levels found in endometriosis patients and higher levels in pregnant patients.

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Abstract

ObjectiveTo evaluate survivin gene expression in granulosa cells from infertile patients and examine the relationship between survivin gene expression and infertile clinical background.DesignProspective study.SettingIVF-ET program at Osaka Medical College.Patient(s)Twenty-eight patients underwent ovulation induction for IVF-ET performed because of tubal infertility, male factor infertility, or endometriosis.Intervention(s)Granulosa cells obtained at oocyte retrieval were examined for survivin gene expression by quantitative reverse transcription-polymerase chain reaction.Main outcome measure(s)Hormone environment, number of oocytes, fertilization rate, high-quality embryo rate, pregnancy rate, and expression of survivin genes.Result(s)Survivin gene expression was detected in all granulosa cells. The gene expression levels of survivin in patients with endometriosis were significantly lower than those in patients with male factor infertility. The gene expression levels of survivin in total pregnant patients were higher than those in total nonpregnant patients and than those in the male factor infertility group, and there was no correlation between gene expression level and serum E(2) level.Conclusion(s)Survivin may be used as an indicator of the success of IVF-ET, and the existence of endometriosis may elevate the apoptosis of granulosa cells.

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Condition tags

endometriosis

MeSH descriptors

Embryo Transfer Fertilization in Vitro Gene Expression Regulation, Developmental Granulosa Cells Infertility Microtubule-Associated Proteins Neoplasm Proteins Adult Apoptosis Biomarkers Biomarkers Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Estradiol Estradiol Fallopian Tube Diseases Fallopian Tube Diseases

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