Influence of severe endometriosis on gene expression of vascular endothelial growth factor and interleukin-6 in granulosa cells from patients undergoing controlled ovarian hyperstimulation for in vitro fertilization-embryo transfer

Yoshiki Yamashita, Yamashita Y, Masatsugu Ueda, Ueda M, Takehara M, Mikio Takehara, Hikari Yamashita, Yamashita H, Suzuki Y, Yoshihiko Suzuki, Yao-Ching Hung, Yao‐Ching Hung, Hung YC, Terai Y, Yoshito Terai, Ueki M, Minoru Ueki
Fertility and sterility · 2002 · vol. 78(4) , pp. 865–871 · doi:10.1016/s0015-0282(02)03339-3 · PMID:12372470 · W2171698950
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This study investigated the impact of severe endometriosis on vascular endothelial growth factor and interleukin-6 gene expression in granulosa cells from women undergoing IVF.

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Abstract

ObjectiveTo evaluate how endometriosis affects expression of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) in granulosa cells.DesignProspective study.SettingIVF-ET program at Osaka Medical College.Patient(s)Seventeen patients with revised American Fertility Society stage IV endometriosis and 17 patients with tubal infertility and no endometriosis.Intervention(s)Granulosa cells obtained at oocyte retrieval were examined for VEGF and IL-6 gene expression.Main outcome measure(s)Serum E(2) and P levels at hCG administration, number of oocytes, fertilization rate, high-quality embryo rate, and pregnancy rate, and expression of VEGF and IL-6 genes.Result(s)Total hMG and FSH levels were statistically significantly higher in patients with endometriosis; however, the number of retrieved oocytes and the fertilization rate were lower compared with patients with tubal infertility. Serum E(2) levels and expression of VEGF in patients with tubal infertility were statistically significantly higher than those in patients with endometriosis. Interleukin-6 gene expression did not differ between the groups.Conclusion(s)In severe endometriosis, lower VEGF gene expression in granulosa cells may adversely affect oocyte development and maturation.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endothelial Growth Factors Gene Expression Granulosa Cells Intercellular Signaling Peptides and Proteins Interleukin-6 Lymphokines Reproductive Techniques, Assisted Chorionic Gonadotropin Chorionic Gonadotropin Embryo Transfer Endometriosis Endometriosis Endothelial Growth Factors Estradiol Estradiol Fallopian Tube Diseases Fallopian Tube Diseases Female Fertilization in Vitro

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