Expression, production, and secretion of vascular endothelial growth factor and interleukin-6 by granulosa cells is comparable in women with and without endometriosis

N Garrido, Nicolás Garrido, Carmela Albert, C Albert, Albert C, Jan-Steffen Krüssel, Krüssel JS, J S Krüssel, José‐Enrique O’Connor, J E O'Connor, O'Connor JE, J Remohí, Remohí J, José Remohı́, C Simón, Carlos Simón, A Pellicer, António Pellicer, Pellicer A
Fertility and sterility · 2001 · vol. 76(3) , pp. 568–575 · doi:10.1016/s0015-0282(01)01961-6 · PMID:11532483 · W2140856153
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Granulosa cells from women with and without endometriosis produced and secreted comparable levels of vascular endothelial growth factor and interleukin-6.

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Abstract

ObjectiveTo investigate the production and secretion of interleukin (IL)-6 and vascular endothelial growth factor (VEGF) mRNA and protein by granulosa luteal cells (GCs) in vivo and in vitro in women with and without endometriosis.DesignProspective study.SettingA private, university-affiliated assisted reproduction unit and a university center.Patient(s)Women with severe endometriosis (n = 6) or without the disease (n = 14) after laparoscopy, undergoing in vitro fertilization/intracytoplasmic sperm injection and embryo transfer.Intervention(s)GCs were obtained from each aspirate.Main outcome measure(s)Intracellular and secreted protein, as well as mRNA for both VEGF and IL-6 in GCs.Result(s)The expression of VEGF and IL-6 mRNAs in vivo and in vitro was similar in both groups. Also, GCs from patients with endometriosis produced and secreted equal amounts of these proteins compared with controls without the disease, either in freshly isolated cells or in 24-hour cultures.Conclusion(s)The GC function in terms of VEGF and IL-6 production does not seem to be altered in patients with endometriosis in comparison with those without this condition.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endothelial Growth Factors Endothelial Growth Factors Granulosa Cells Interleukin-6 Interleukin-6 Lymphokines Lymphokines Cells, Cultured Culture Media, Conditioned DNA Primers Embryo Transfer Endometriosis Endometriosis Endothelial Growth Factors Enzyme-Linked Immunosorbent Assay Female Fertilization in Vitro Flow Cytometry Granulosa Cells

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