Expression of interleukin-6 and interleukin-6 receptors in human granulosa lutein cells
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This study found that human granulosa lutein cells express interleukin-6 and its receptor, and that IL-6 inhibits HCG-induced progesterone secretion from these cells.
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Abstract
Cytokines are important regulators of reproductive functions. Significant amounts of interleukin-6 (IL-6) have been detected in the serum and ascites of patients with ovarian hyperstimulation syndrome (OHSS). These findings suggest the involvement of IL-6 as a mediator in the pathogenesis of OHSS. This study was performed to analyse IL-6 and IL-6 receptor (IL-6-R) expression in human granulosa lutein cells (GC). GC were cultured after isolation from follicular fluid. IL-6 concentrations in follicular fluid and serum from individual patients and GC supernatants were measured by enzyme-linked immunosorbent assay. We found detectable concentrations of IL-6 in serum and follicular fluid of all patients. Expression of IL-6 in GC was shown immunocytochemically. IL-6 mRNA was detected in GC by in-situ hybridization. Gene expression for IL-6 and IL-6-R in GC was demonstrated using reverse transcription-polymerase chain reaction. IL-6 significantly inhibited human chorionic gonadotrophin (HCG)-induced progesterone secretion of GC. The results of our study suggest that IL-6 is expressed in HGC and that this cytokine is able to modulate GC function via its specific receptor. This is the first report that describes the precence of IL-6-R in human granulosa lutein cells.
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Cites (3)
- Elevated levels of interleukin-6 in ascites and serum from women with ovarian hyperstimulation syndrome 1993
- Elevated interleukin-6 levels in the ovarian hyper stimulation syndrome: Ovarian immunohistochemical localization of interleukin-6 signal 1996
- Elevated levels of interleukin-6 in the follicular fluid at the time of oocyte retrieval for in vitro fertilization may predict the development of early-form ovarian hyperstimulation syndrome 1997
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organisms 4
human
human
human
human
chemicals 1
progesterone
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