How does endometriosis affect infertility?

José A. Navarro, Navarro J, José Navarro, Nicolás Garrido, Remohí J, José Remohí, J. Remohı́, António Pellicer, Antonio Pellicer
Obstetrics and Gynecology Clinics of North America · 2003 · vol. 30(1) , pp. 181–192 · doi:10.1016/s0889-8545(02)00060-8 · PMID:12699265 · W2047710832
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This paper explores the mechanisms by which endometriosis contributes to infertility, focusing on inflammation, altered pelvic anatomy, and hormonal imbalances.

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Abstract

Prospective and retrospective clinical trials suggest a decreased oocyte and embryo quality in women with endometriosis. Based on these observations, the authors described an altered intrafollicular milieu in endometriosis, which explains the bad quality oocytes and the resulting embryos with lower capacity to implant. Whether these changes affect the oocytes or are the consequence of genomic alterations manifested by biochemical and chromosomal differences in healthy women is an unresolved issue. If the effects of endometriosis on follicular development are nongenomic in origin, modulation of the process of folliculogenesis may be sufficient to treat the disease and cure infertility associated with endometriosis. A genomic defect needs specific genetic therapy, which currently is not available.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Ovarian Diseases Endometriosis Endometriosis Female Fertilization in Vitro Humans Infertility, Female Infertility, Female Oocyte Donation Ovarian Diseases Ovarian Diseases Ovarian Follicle Ovarian Follicle

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (64)

Cited by (30)

Source provenance

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License: CC0 · commercial use OK