Increased incidence of aberrant morphological phenotypes in human embryogenesis—An association with endometriosis

Cathy L. Brizek, C L Brizek, Brizek CL, S Schlaff, Schlaff S, Sheldon Schlaff, Vincent A. Pellegrini, Pellegrini VA, V A Pellegrini, Frank JB, J B Frank, Jeffrey B. Frank, Worrilow KC, Kathryn C. Worrilow, K C Worrilow
Journal of assisted reproduction and genetics · 1995 · vol. 12(2) , pp. 106–112 · doi:10.1007/bf02211378 · PMID:7670267 · W1969263330
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⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-06-08 ⓘ

This study examined 235 embryos from women undergoing IVF and found a statistically increased incidence of aberrant nuclear and cytoplasmic events in embryos from women with endometriosis compared to controls.

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This retrospective study analyzed 235 embryos from 30 women undergoing 56 IVF cycles, categorizing embryos by specific aberrant nuclear and cytoplasmic morphological criteria observed on days 1 and 2 after oocyte retrieval. Compared with controls, several defined aberrant embryonic morphological events were found to be statistically increased in embryos from women with laparoscopically documented endometriosis. The authors conclude that these defined phenotypes may reflect embryo-toxic events associated with endometriosis, while acknowledging that the study’s design is retrospective and based on morphology categories derived from observational criteria on videotape. This paper is centrally about endometriosis — it reports an increased incidence of aberrant embryo morphological phenotypes in human embryogenesis among women with endometriosis.

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Abstract

PurposeAfter noticing specific aberrant forms of development in preimplantation embryos from women with endometriosis, we embarked upon this study in order to examine the frequency of these events as compared with controls.MethodsA total of 235 embryos representing 30 women undergoing 56 cycles of in vitro fertilization were retrospectively analyzed on videotape and placed into categories based upon the incidence of specific morphological criteria found during observations made on the first and second days following oocyte retrieval.ResultsSeveral of the aberrant nuclear and cytoplasmic events were found to be statistically increased in the group of embryos from women with endometriosis.ConclusionsThe incidence of defined aberrant phenotypes in embryos from women with laparoscopically documented endometriosis may allow us to identify specific embryotoxic events with reference to endometriosis and other diagnoses.
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Abstract

Purpose After noticing specific aberrant forms of development in preimplantation embryos from women with endometriosis, we embarked upon this study in order to examine the frequency of these events as compared with controls.

Methods

A total of 235 embryos representing 30 women undergoing 56 cycles of in vitrofertilization were retrospectively analyzed on videotape and placed into categories based upon the incidence of specific morphological criteria found during observations made on the first and second days following oocyte retrieval.

Results

Several of the aberrant nuclear and cytoplasmic events were found to be statistically increased in the group of embryos from women with endometriosis.

Conclusions

The incidence of defined aberrant phenotypes in embryos from women with laparoscopically documented endometriosis may allow us to identify specific embryotoxic events with reference to endometriosis and other diagnoses. Similar content being viewed by others

References

Ron-El R, Nachum H, Herman A, Golan A, Caspi E, Soffer Y: Delayed fertilization and poor embryonic development associated with impaired semen quality. Fertil Steril 1991;55:338–344 Prainaud J, Mieusset R, Vieitez G, Labal B, Richoilley G: Influence of sperm parameters on embryo quality. Fertil Steril 1993;60:888–892 Fishel S, Jackson P, Webster J, Faratian B: Endotoxins in culture medium for human in vitro fertilization. Fertil Steril 1988;49:108–111 Vasquez-Levin M, Kaplan P, Guzman I, Grunfeld L, Garrisi GJ, Navot D: The effect of female antisperm antibodies on in vitro fertilization, early embryonic development, and pregnancy outcome. Fertil Steril 1991;56:84–88 Michaeli G, Fejgin M, Ghetler Y, Ben Nun I, Beyth Y, Amiel A: Chromosomal analysis of unfertilized oocytes and morphologically abnormal preimplantation embryos from an in vitro fertilization program. J in Vitro Fertil Embryo Transfer 1990;7:341–346 Damewood MD, Hesla JS, Schlaff WD, Hubbard M, Gearhart JD, Rock JA: Effect of serum from patients with minimal to mild endometriosis on mouse embryo development in vitro. Fertil Steril 1990;54:917–920 Simon C, Gomez E, Mir A, De los Santos M, Pellicer A: Glucocorticoid treatment decreases sera embryotoxicity in endometriosis patients. Fertil Steril 1992;58:284–289 Morcos RN, Gibbons WE, Findley WE: Effect of peritoneal fluid on in vitro cleavage of 2-cell mouse embryos: possible role in infertility associated with endometriosis. Fertil Steril 1985:44:678–683 Remohi J, Vidal A, Pellicer A: Oocyte donation in low level responders to conventional ovarian stimulation for in vitro fertilization. Fertil Steril 1993:59:1208–1215 Shulman A, Ben-Nun I, Ghetler Y, Kaneti H, Shilon M, Beyth Y: Relationship between embryo morphology and implantation rate after in vitro fertilization treatment in conception cycles. Fertil Steril 1993;60:123–126 Simon C, Gutierrez A, Vidal A, de los Santos MJ, Tarin JJ, Remohi J, Pellicer A: Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation. Hum Reprod 1994;9:725–729 Mahmood TA, Messinis IE, Templeton A: Follicular development in spontaneous and stimulated cycles in women with minimal-mild endometriosis. Br J Obstet Gynaecol 1991;98: 783–788 Author information Authors and Affiliations Rights and permissions About this article Cite this article Brizek, C.L., Schlaff, S., Pellegrini, V.A. et al. Increased incidence of aberrant morphological phenotypes in human embryogenesis—An association with endometriosis. J Assist Reprod Genet 12, 106–112 (1995). https://doi.org/10.1007/BF02211378 Received: Accepted: Issue date: DOI: https://doi.org/10.1007/BF02211378

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Condition tags

endometriosis

MeSH descriptors

Blastocyst Endometriosis Fertilization in Vitro Blastocyst Cell Nucleus Cell Nucleus Cytoplasm Cytoplasm Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Microscopy, Video Organelles Organelles Phenotype Retrospective Studies

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