Glucocorticoid treatment decreases sera embryotoxicity in endometriosis patients

Carlos Simón, C Simón, E Gómez, Gómez E, Emilio Gómez, A. Mir, Mir A, María José de los Santos, M J De los Santos, de Los Santos MJ, A Pellicer, António Pellicer, Pellicer A
Fertility and Sterility · 1992 · vol. 58(2) , pp. 284–289 · doi:10.1016/s0015-0282(16)55198-x · PMID:1633892 · W2418928039
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Glucocorticoid treatment was found to reduce the embryotoxicity observed in the sera of patients diagnosed with endometriosis.

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Abstract

ObjectiveTo investigate the effect of short-term glucocorticoid administration on embryotoxicity of sera from infertile patients with mild to moderate endometriosis.DesignProspective longitudinal study.Setting, patientsEight infertile patients with mild to moderate endometriosis and a control group of eight infertile patients with tubal infertility were selected on the basis of laparoscopic examination.InterventionsBasal (B) serum collection and day 1 (T1), day 3 (T2), day 6 (T3), and day 12 (T4) serum drawn after a 3-day glucocorticoid treatment in endometriosis patients.Main outcome measureEmbryotoxicity of endometriosis sera, before and after glucocorticoid treatment, was investigated using a bioassay performed on two-cell mouse embryos. Interleukin 1 alpha (IL-1 alpha) and antismooth muscle, antimitochondrial, and antinuclear autoantibodies were also tested in these sera.ResultsAt 50% concentration, endometriosis serum is embryotoxic in comparison with control; 0% versus 61% of the embryos reached the blastocyst stage at 72 hours, respectively (basal versus control, P less than 0.001). However, this embryotoxicity significantly decreases 12 days after glucocorticoid treatment in comparison with untreated sera; 32.4% versus 0% of the embryos reached blastocyst stage at 72 hours, respectively (T4 versus basal, P less than 0.001), although they did not reach nontoxic levels (greater than 50%). Interleukin 1 alpha was undetectable in all samples analyzed. In endometriosis sera, antismooth muscle antibody was detected.ConclusionsAt 50% concentration, serum from infertile patients with minimal to moderate endometriosis appears to be embryotoxic to the in vitro development of two-cell mouse embryos. However, this embryotoxicity significantly decreases 12 days after a 3-day treatment with glucocorticoids.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Fetal Death Infertility, Female Methylprednisolone Hemisuccinate Adult Animals Blastocyst Blastocyst Blood Culture Techniques Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Longitudinal Studies Methylprednisolone Hemisuccinate Mice Morula

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