An association of IgG anti-laminin-1 autoantibodies with endometriosis in infertile patients

Inagaki J, Junko Inagaki, Sugiura-Ogasawara M, Mayumi Sugiura-Ogasawara, Motoyoshi Nomizu, Nomizu M, Nakatsuka M, Mikiya Nakatsuka, Katsuo Ikuta, Ikuta K, Nobuharu Suzuki, Suzuki N, Keiko Kaihara, Kaihara K, Kobayashi K, Kazuko Kobayashi, Tatsuji Yasuda, Yasuda T, Yehuda Shoenfeld, Shoenfeld Y, Koji Aoki, Aoki K, Eiji Matsuura
Human Reproduction · 2003 · vol. 18(3) , pp. 544–549 · doi:10.1093/humrep/deg148 · PMID:12615822 · W2102410942
article OA: bronze CC0 ⤵ 40 in-corpus citations
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IgG anti-laminin-1 autoantibodies were significantly associated with endometriosis in infertile patients and recognized the laminin-alpha1 chain G domain, with related mRNA expressed in endometriotic lesions.

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Abstract

BACKGROUND: Laminin-1, a multifunctional glycoprotein of the basement membrane, is thought to be important in embryogenesis, embryonic implantation, and placentation. We recently showed that serum IgG anti-laminin-1 autoantibodies (auto-Abs) are associated with recurrent first-trimester miscarriages. The present study assessed the clinical significance of anti-laminin-1 Abs with infertility, accompanied with or without endometriosis. METHODS: Sixty-eight infertile patients who underwent laparoscopy or laparotomy and 39 healthy non-pregnant women were tested for IgG anti-laminin-1 Abs. The association between the Abs and endometriosis was analysed. The presence of laminin-1 mRNA was detected in endometriotic lesions. RESULTS: Twenty infertile patients were positive for anti-laminin-1 Abs. The Ab levels in those patients were significantly higher than those in healthy non-pregnant women (P = 0.0005). The presence of the Abs was significantly associated with endometriosis in those patients (P = 0.0096). The Abs recognized a particular domain, i.e., the laminin-alpha1 chain G domain. mRNA encoding laminin-alpha1, -beta1, and -gamma1 chains was expressed in 90% of endometriotic lesions. CONCLUSIONS: IgG anti-laminin-1 Abs were significantly associated with endometriosis in infertile patients. The Abs might be clinically important in the development of autoimmune-mediated reproductive failures and the assessment of the Abs may provide a novel non-invasive diagnosis of endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Autoantibodies Endometriosis Immunoglobulin G Infertility, Female Infertility, Female Laminin Adult Autoantibodies Case-Control Studies Endometriosis Endometriosis Female Humans Immunoglobulin G Infertility, Female Laminin Laminin RNA, Messenger RNA, Messenger

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