Multiple endometrial antigens are targeted in autoimmune endometriosis

R Gajbhiye, Rahul Gajbhiye, Amol Ratnakar Suryawanshi, A Suryawanshi, Suryawanshi A, Khan S, Shagufta Khan, S Khan, Meherji P, Pervin Meherji, P Meherji, Warty N, Neeta Warty, N Warty, Raut V, V Raut, Vivek Raut, Chehna N, N Chehna, V Khole, Vrinda V. Khole, Khole V
Reproductive BioMedicine Online · 2008 · vol. 16(6) , pp. 817–824 · doi:10.1016/s1472-6483(10)60147-2 · PMID:18549691 · W2010768914
article OA: bronze CC0 ⤵ 30 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

Researchers identified multiple endometrial antigens as targets in autoimmune endometriosis, suggesting a potential role for immune responses in the disease's pathogenesis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is defined as the growth of endometrial glands and stroma in ectopic locations. Its aetiology is multifactorial, but autoimmunity has been shown to play a role in its onset and development. The present study aimed to investigate the presence of both IgG and IgM anti-endometrial antibodies in sera of endometriosis patients in comparison with age-matched controls, and to also investigate the cognate endometrial proteins involved. Sera from these groups were screened by western blot and immunohistochemistry. Thirteen out of the 40 sera tested were positive for IgG isotype, and 10/27 IgG negative patients were positive for IgM isotype. These findings indicate that endometrial antibodies of IgG and IgM classes could be detected in almost 60% of endometriosis patients. Of the various identified endometrial antigens, 30 and 45 kDa antigens were immunodominant in both IgG and IgM positive endometriosis patients. With immunohistochemistry, positive sera showed reactivity in luminal epithelium, glandular epithelium and stroma. These anti-endometrial antibodies might be partially responsible for failure of implantation leading to infertility. Identification of specific targets would be a help in understanding the pathophysiology of endometriosis, and would also help in setting up a non-invasive test for the diagnosis of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Autoantigens Autoimmune Diseases Endometriosis Immunoglobulin G Immunoglobulin M Autoantigens Autoimmune Diseases Blotting, Western Case-Control Studies Endometriosis Female Humans Immunoglobulin G Immunoglobulin M Immunohistochemistry Prospective Studies

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (42)

Cited by (29)

Source provenance

europepmc
last seen: 2026-09-27T09:11:36.575535+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:14:30.652814+00:00
License: CC0 · commercial use OK