Antiendometrial Autoantibodies Are Generated in Patients With Endometriosis

Itsuo Gorai, I Gorai, M Ishikawa, Masahiko Ishikawa, Ryo Onose, R Onose, Fumiki Hirahara, F Hirahara, H Minaguchi
American journal of reproductive immunology (New York, N.Y. : 1989) · 1993 · vol. 29(2) , pp. 116–123 · doi:10.1111/j.1600-0897.1993.tb00575.x · PMID:8329104 · W2060158976
article OA: closed CC0 ⤵ 16 in-corpus citations
View on OpenAlex View on PubMed View at publisher

Abstract

PROBLEM: Our aim was to investigate endometrial antigens involved in the autoimmunity of endometriosis. METHOD: We detected endometrial antigens against which autoantibodies directed with Western blotting. RESULTS: Thirteen (72.2%), 14 (77.8%), and 15 (83.3%) of 18 serum samples from endometriosis patients had antibodies reactive against endometrial antigen wtih MW of 26 kd, 34 kd, and 42 kd, respectively, while 6 (33.3%), 8 (44.4%), and 8 (44.4%) of 18 samples from normal control women reacted against these antigens, respectively. The frequencies of antibodies to the endometrial antigens were significantly (P < 0.05) higher in the endometriosis patients than in the normal control women. Antibodies in peritoneal fluid (PF) reacted against antigens with MW of 26, 34, 38, 42, and 64 kd, while those from the normal control reacted against antigens with MW of 38, 42, and 64 kd. Serum samples from normal fertile males did not show any reactivity against these endometrial antigens. CONCLUSIONS: Our results show that autoantibodies reactive against endometrial antigens are present in patients with endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Autoantibodies Autoantigens Endometriosis Endometrium Adult Ascitic Fluid Ascitic Fluid Autoantibodies Autoantibodies Autoantigens Autoantigens Endometriosis Endometrium Female Humans Male Middle Aged Molecular Weight

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (16)

Source provenance

europepmc
last seen: 2026-06-13T06:22:48.782012+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:11:39.448046+00:00
License: CC0 · commercial use OK