F(ab′)2 segment is the active component of immunoglobulin G autoantibody generation in patients with endometriosis

Robert A. Wild, Wild RA, R A Wild, Diane Medders, D Medders, Medders D, Zhang RJ, Renjie Zhang, R J Zhang
Fertility and sterility · 1991 · vol. 56(5) , pp. 900–903 · doi:10.1016/s0015-0282(16)54662-7 · PMID:1718784 · W2417001378
article OA: closed CC0 ⤵ 7 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study investigated the F(ab′)2 segment of immunoglobulin G autoantibodies and determined it is the active component responsible for their generation in patients diagnosed with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo determine if the low titer antiendometrial antibody detection by indirect immunofluorescence (IIF) in the sera of patients with endometriosis is because of specific antigen-antibody interactions.DesignSera of selected patients subjected to separation of immunoglobulin fragments by ammonium sulfate precipitation and pepsin digestion and tested by IIF. In a comparative method, a fragment, crystallizable (Fc) flooding technique was used to determine the active component.SettingSera obtained preoperatively in the outpatient and results matched with surgical findings.Patients/participantsPatients 45 years of age or less presenting for gynecological surgery who had signed an informed consent for the drawing of preoperative blood.InterventionsNone.Main outcome measuresIndirect immunofluorescence was graded according to the intensity of staining and the lowest dilution at which staining occurred.ResultsAll of the sera of the 11 patients with endometriosis exhibited F(ab')2 specific staining but none exhibited Fc fragment staining. None of the 7 control patients displayed F(ab')2 or Fc fragment staining.ConclusionsF(ab')2 fragment is the active component of an immunologically specific interaction when antiendometrial antibodies are detected in the sera of patients with endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Autoantibodies Endometriosis Immunoglobulin Fab Fragments Immunoglobulin G Antibody Formation Autoantibodies Endometriosis Endometriosis Fluorescent Antibody Technique Humans Immunoglobulin Fab Fragments Immunoglobulin Fab Fragments Immunoglobulin G Neoplasm Staging Staining and Labeling Tumor Cells, Cultured

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (14)

Cited by (7)

Source provenance

europepmc
last seen: 2026-07-31T06:09:14.520117+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:11:54.876058+00:00
License: CC0 · commercial use OK