F(ab')2 segment is the active component of immunoglobulin G autoantibody generation in patients with endometriosis

Robert A. Wild, Wild RA, R A Wild, Diane Medders, D Medders, Medders D, Zhang RJ, Renjie Zhang, R J Zhang
Fertility and sterility · 1991 · vol. 56(5) , pp. 900–903 · doi:10.1016/s0015-0282(16)54662-7 · PMID:1718784 · W2417001378
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This study investigated the F(ab′)2 segment of immunoglobulin G autoantibodies and determined it is the active component responsible for their generation in patients diagnosed with endometriosis.

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Abstract

OBJECTIVE: To determine if the low titer antiendometrial antibody detection by indirect immunofluorescence (IIF) in the sera of patients with endometriosis is because of specific antigen-antibody interactions. DESIGN: Sera of selected patients subjected to separation of immunoglobulin fragments by ammonium sulfate precipitation and pepsin digestion and tested by IIF. In a comparative method, a fragment, crystallizable (Fc) flooding technique was used to determine the active component. SETTING: Sera obtained preoperatively in the outpatient and results matched with surgical findings. PATIENTS/PARTICIPANTS: Patients 45 years of age or less presenting for gynecological surgery who had signed an informed consent for the drawing of preoperative blood. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Indirect immunofluorescence was graded according to the intensity of staining and the lowest dilution at which staining occurred. RESULTS: All of the sera of the 11 patients with endometriosis exhibited F(ab')2 specific staining but none exhibited Fc fragment staining. None of the 7 control patients displayed F(ab')2 or Fc fragment staining. CONCLUSIONS: F(ab')2 fragment is the active component of an immunologically specific interaction when antiendometrial antibodies are detected in the sera of patients with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Autoantibodies Endometriosis Immunoglobulin Fab Fragments Immunoglobulin G Antibody Formation Antibody Formation Autoantibodies Autoantibodies Endometriosis Endometriosis Endometriosis Fluorescent Antibody Technique Fluorescent Antibody Technique Humans Humans Immunoglobulin Fab Fragments Immunoglobulin Fab Fragments Immunoglobulin Fab Fragments Immunoglobulin G Immunoglobulin G

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (14)

Cited by (7)

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