Detection of Antiendometrial Antibodies in Patients With Endometriosis by Cell ELISA

H Hatayama, Hiroshi Hatayama, K Imai, Kimitoshi Imai, Hideharu Kanzaki, H Kanzaki, Toshihiro Higuchi, T Higuchi, Mariko Fujimoto, M Fujimoto, Takahide Mori, T Mori
American journal of reproductive immunology (New York, N.Y. : 1989) · 1996 · vol. 35(2) , pp. 118–122 · doi:10.1111/j.1600-0897.1996.tb00017.x · PMID:8839140 · W2075289414
article OA: closed CC0 ⤵ 13 in-corpus citations
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This study utilized cell ELISA to find significantly higher levels and positive rates of antiendometrial antibodies in infertile patients with endometriosis compared to those without.

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Abstract

PROBLEM: To determine whether infertile patients with endometriosis have serum antiendometrial antibodies. METHODS: Sera from 40 infertile patients with or without endometriosis were tested by cell enzyme-linked immunosorbent assay (ELISA), in which endometrial cancer cells were used as endometrial antigens, and uterine cervix cancer cells as control antigens. As a negative control, eight healthy adult males were included. The level greater than the mean +/- 2 standard deviations (SD) of the male control group was judged positive. RESULTS: The mean value of antiendometrial antibody level was significantly higher in patients with endometriosis than in those without endometriosis (ANOVA, P < 0.01). The frequency of antiendometrial antibody-positive patients was also higher in the former than in the latter (chi 2 test, P < 0.05). However, when uterine cervix cancer cells were used as antigens, no difference was observed in the mean antibody levels or in the positive rates between the two groups. CONCLUSIONS: Endometriosis seems to be associated with autoantibody production against the endometrium-related antigen(s).

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Condition tags

endometriosis

MeSH descriptors

Autoantibodies Endometriosis Endometrium Enzyme-Linked Immunosorbent Assay Adult Autoantibodies Endometriosis Endometrium Female Humans

Citation neighborhood

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References (21)

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