Serum Antiendometrial Antibodies and Diagnosis of Endometriosis

Gary W Randall, Pickens A Gantt, Robin L. Poe‐Zeigler, Robin L Poe-Zeigler, Cynthia A Bergmann, Marshall E Noel, Wendy R Strawbridge, Barbara Richardson‐Cox, Barbara Richardson-Cox, John R Hereford, Robert H Reiff
American journal of reproductive immunology (New York, N.Y. : 1989) · 2007 · vol. 58(4) , pp. 374–382 · doi:10.1111/j.1600-0897.2007.00523.x · PMID:17845208 · W2140701484
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This multi-center study found that a serum antiendometrial antibody assay demonstrated high sensitivity and specificity, making it a good screening test for suspected endometriosis prior to laparoscopy.

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Abstract

PROBLEM: The purpose of the present prospective multi-center study is to investigate the relationship between laparoscopic diagnosis of endometriosis and results of a serum antiendometrial antibody (AEA) assay. METHOD OF STUDY: Indirect immunofluorescence detection of AEA was performed on serum specimens from patients presenting with dysmenorrhea or chronic pelvic pain and infertility (n = 2609) utilizing frozen sections of endometrium acquired on cycle days 18-21 from normally cycling women without endometriosis. Diagnostic laparoscopy was performed within 1 year of AEA assay on 527 tested women. RESULTS: The relationship between the serum AEA and laparoscopic verification was characterized by a positive predictive value = 88%, negative predictive value = 86%, sensitivity = 87% and specificity = 87%. CONCLUSION: The AEA assay is a very good screening test for patients suspected of having endometriosis and should be utilized prior to laparoscopy in diagnostic categories of dysmenorrhea or chronic pelvic pain and infertility.

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Condition tags

dysmenorrheaendometriosischronic_pelvic_paininfertility

MeSH descriptors

Autoantibodies Endometriosis Endometrium Fluorescent Antibody Technique, Indirect Laparoscopy Mass Screening Autoantibodies Dysmenorrhea Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Endometriosis Endometrium Female Humans Infertility Infertility Infertility Mass Screening

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (77)

Cited by (28)

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