The Role of Biomarkers in the Early Diagnosis of Endometriosis

Dominic Worku
In: Investigations in Gynecology Research & Womens Health (IGRWH) · 2017 · vol. 1(3) · doi:10.31031/igrwh.2017.01.000512 · W2801077236
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper discusses the potential of biomarkers for the early diagnosis of endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This paper is a 2008–2017 mini-review examining biomarkers and diagnostic investigations aimed at earlier diagnosis of endometriosis, summarizing evidence from databases such as PubMed and Cochrane. It describes diagnostic challenges including long delays to diagnosis, the limitations of laparoscopy (including possible visual misclassification), and modest transvaginal ultrasound sensitivity, while noting MRI performance as higher but resource-intensive and cycle-phase dependent; key biomarker findings focus on CA-125 and potential biomarker panels (e.g., CA-125 combined with VEGF, Annexin V, and sICAM1) with broadly variable sensitivity/specificity, and on emerging circulating microRNAs with differential expression in patients versus controls. A major caveat stated is that biomarker performance varies widely and requires validation across age and ethnicity, and that CA-125 alone has low specificity. This paper is centrally about endometriosis — it reviews biomarkers and diagnostic approaches for early identification of endometriosis.

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Abstract

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (21)

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last seen: 2026-06-10T17:14:06.276822+00:00
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