Autoimmunity to Endometrium and Ovary in Endometriosis

Subbi Mathur, M.R. Peress, H. Oliver Williamson, C. D. YOUMANS, S. A. MANEY, A. Julian Garvin, P. F. Rust, H. Hugh Fudenberg
In: Obstetrical & Gynecological Survey · 1983 · vol. 38(9) , pp. 587 · doi:10.1097/00006254-198309000-00022 · W1963935145
article OA: green CC0 ⤵ 119 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study found significantly elevated antibody titers to the endometrium and ovary in the sera of endometriosis patients compared to controls, with IgG and IgA identified as the primary immunoglobulin types.

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Abstract

Antibody titres to whole ovary, theca cells, granulosa cells and endometrium were determined by passive haemagglutination and immunofluorescence assays in sera and in cervical and vaginal secretions from 13 patients with endometriosis. Antibody titres to endometrium (mean log2 +/- s.e.m., 7.08 +/- 0.80; P less than 0.0001), ovary (3.58 +/- 0.87; P = 0.0092), theca cells (4.42 +/- 0.73; P less than 0.0001) and granulosa cells (3.33 +/- 0.63; P = 0.0024) were significantly higher in the patients' sera than in sera from 15 normal non-pregnant females. Antibody titres to granulosa cells were elevated (7.97 +/- 1.46; P = 0.0424) in their cervical secretions. Antibody titres to all tissues tested were similar in vaginal secretions of patients and controls. Immunofluorescent antibody assay of biopsied endometrial tissue and sera from the patients revealed the antibodies to be primarily IgG and IgA. The results suggest that autoantibodies to endometrium and ovary are present in patients with endometriosis.

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Condition tags

endometriosis

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