Autoantibodies: Key Mediators of Autoimmune Infertility

Kaushiki M. Kadam, Purvi Mande, Asmita Choudhury
In: Autoantibodies and Cytokines · 2019 · doi:10.5772/intechopen.73899 · W2912422719
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This chapter explores autoimmune infertility in females, highlighting the need for better diagnostic biomarkers and management strategies beyond current organ-specific panels by focusing on natural antibodies as autoantibodies.

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Abstract

Autoimmune diseases have gender bias with predominance in females, autoimmune infertility (AI) being no exception. This chapter will focus on AI in females with brief reference to the same in males. Autoimmune diseases have established protocols for detection and management of ensuing infertility, however similar protocols for unexplained infertility [tubal blockage, endometriosis, premature ovarian insufficiency (POI), undiagnosed underlying autoimmune disease (Sjögren’s syndrome, IBS, celiac disease) and tubal blockage] are not established. Endometriosis and POI, in particular, have autoimmune etiology yet lack specific and sensitive biomarkers for accurate diagnosis. If autoantibodies are indeed diagnosed, then treatment regimen focuses on AI which has known adverse effects. The detection of natural antibodies as autoantibodies presents a viable alternative to organ specific biomarker panel for better management of AI.

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Condition tags

endometriosisinfertility

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