Ovarian failure and polycystic ovary syndrome

Jana Petríková, Ivica Lazúrová
Autoimmunity reviews · 2011 · vol. 11(6-7) , pp. A471–A478 · doi:10.1016/j.autrev.2011.11.010 · PMID:22154711 · W1978877322
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This paper reviews the relationship between ovarian failure and polycystic ovary syndrome, discussing their shared and distinct characteristics.

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Abstract

The human ovary is commonly the target of an autoimmune attack leading to the ovarian dysfunction which can be manifested as premature ovarian failure (POF), polycystic ovary syndrome (PCOS), unexplained infertility as well as endometriosis. In case of POF, the evidence for an autoimmune etiology is based on the presence of lymphocytic oophoritis, autoantibodies to ovarian antigens and association with other autoimmune disorders, which was clearly documented in many studies. The search for antiovarian antibodies has been undertaken in numerous studies, especially in patients with POF, however their results are still conflicting particularly due to difference in laboratory methods as well as many ovarian components being potential antigens. On the other side the autoimmune etiology of PCOS is still debated and was documented in some cases. Association of PCOS with non-organ specific autoimmune disorders is controversial; however association with autoimmune thyroid disease was well demonstrated in some studies.

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Condition tags

endometriosis

MeSH descriptors

Autoimmunity Polycystic Ovary Syndrome Primary Ovarian Insufficiency Autoimmune Diseases Autoimmune Diseases Autoimmunity Endometriosis Endometriosis Female Humans Immunosuppressive Agents Immunosuppressive Agents Ovary Ovary Polycystic Ovary Syndrome Primary Ovarian Insufficiency Thyroiditis, Autoimmune Thyroiditis, Autoimmune Thyroiditis, Autoimmune

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References (100)

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License: CC0 · commercial use OK