IgG, IgA and IgM Antibodies against FSH: Serological Markers of Pathogenic Autoimmunity or of Normal Immunoregulation?

Kadri Haller, Christine Mathieu, Chantal Mathieu, Kristiina Rull, Kadri Matt, Marie C Béné, Raivo Uibo
American journal of reproductive immunology (New York, N.Y. : 1989) · 2005 · vol. 54(5) , pp. 262–269 · doi:10.1111/j.1600-0897.2005.00306.x · PMID:16212648 · W1985735967
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This study investigated anti-FSH antibodies in infertile women with PCOS and endometriosis, finding elevated IgA and IgG levels in patients compared to controls and pregnant women.

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Abstract

PROBLEM: Autoimmune mechanisms are often involved in causing infertility. Among the possible targets of autoantibodies, the follicle-stimulating hormone (FSH) which regulates the follicular maturation in human ovary is a promising candidate. We aimed to study whether anti-FSH-antibodies might be involved in different clinical types of infertility. METHOD OF STUDY: The study group consisted of 178 patients (75 with polycystic ovary syndrome (PCOS), 103 with endometriosis) and 75 pregnant women. Female blood donors formed the control group (n = 85). Indirect enzyme-linked immunosorbent assay tests were performed using purified FSH as antigens and a synthetic peptide corresponding to the 78-93 region (V14D) of the human FSH beta-chain. CONCLUSION: We showed that anti-FSH-antibodies were present in controls and their production decreased during pregnancy. Endometriosis and PCOS were associated with higher values of anti-FSH-immunoglobulin (Ig)A, anti-V14D-IgA, and endometriosis with anti-V14D-IgG. Our data suggest that anti-FSH-IgA could be a marker of ovarian disorders that cause infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Autoantibodies Endometriosis Follicle Stimulating Hormone, beta Subunit Polycystic Ovary Syndrome Pregnancy Adult Autoantibodies Autoantibodies Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Endometriosis Endometriosis Female Follicle Stimulating Hormone, beta Subunit Humans Infertility, Female Infertility, Female Infertility, Female Polycystic Ovary Syndrome

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