Putative Predictors of Antibodies Against Follicle‐Stimulating Hormone in Female Infertility: A Study Based on In Vitro Fertilization Patients

Kadri Haller, Haller K, Andres Salumets, Marina Grigorova, Talja I, Ija Talja, Salur L, Liina Salur, Marie Christine Béné, Marie C. Béné, Béné MC, Maris Laan, Raivo Uibo
American journal of reproductive immunology (New York, N.Y. : 1989) · 2007 · vol. 57(3) , pp. 193–200 · doi:10.1111/j.1600-0897.2006.00462.x · PMID:17295898 · W2040070442
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This study found that anti-FSH antibodies in IVF patients are associated with peripheral FSH levels, IVF history, PCOS, endometriosis, unexplained infertility, common autoantibodies, and HLA-DQB1 alleles.

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Abstract

PROBLEM: We have previously demonstrated the presence of naturally occurring antibodies against follicle-stimulating hormone (FSH) in patients with endometriosis and polycystic ovary syndrome (PCOS). Here, we investigated the parameters associated with anti-FSH antibodies in in vitro fertilization (IVF) patients. METHODS OF STUDY: The following parameters were studied in 135 patients: peripheral FSH levels, FSH beta-subunit gene (FSHB) haplotypes, history of previous IVF, and susceptibility to autoimmune reactions in general [seven common autoantibodies (against nuclear antigens on human and rodent substrates, smooth muscle, gastric parietal cells, beta2-glycoprotein I, cardiolipin, and thyroid peroxidase) and HLA-DQB1 alleles]. RESULTS: Although the anti-FSH levels were higher in patients when compared with controls, those higher levels were not associated with FSHB haplotypes. The anti-FSH IgM associated with (i) the levels of FSH in women with male and tubal factor infertility; (ii) the history of IVF in patients with PCOS, endometriosis, and unexplained infertility; and (iii) the production of common autoantibodies among all IVF patients. The anti-FSH IgA associated with HLA-DQB1*03. The anti-FSH IgG correlated with the values of anti-FSH IgA and IgM. CONCLUSION: Anti-FSH may be naturally occurring antibodies associated with peripheral FSH concentrations, but increased in infertile women with dysregulation of immune reactions and repeatedly performed IVF.

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Condition tags

endometriosisinfertility

MeSH descriptors

Autoantibodies Fertilization in Vitro Follicle Stimulating Hormone Infertility, Female Adult Autoantibodies Autoantibodies Autoantigens Autoantigens Female Follicle Stimulating Hormone Follicle Stimulating Hormone Follicle Stimulating Hormone, beta Subunit Follicle Stimulating Hormone, beta Subunit Haplotypes HLA-DQ Antigens HLA-DQ Antigens HLA-DQ beta-Chains Humans Immunoglobulin A

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