Selenium-Binding Protein 1 (SBP1) autoantibodies in ovarian disorders and ovarian cancer

Yi Yu-Rice, Seby Edassery, Seby L Edassery, Nicole Urban, Ingegerd Hellstrom, Ingegerd Hellström, Karl Erik Hellström, Karl Erik Hellstrom, Youping Deng, Yan Li, Judith L Luborsky
Reproduction (Cambridge, England) · 2016 · vol. 153(3) , pp. 277–284 · doi:10.1530/rep-16-0265 · PMID:27965399 · W2561623215
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Selenium-binding protein 1 (SBP1) autoantibodies were found in women with infertility and serous ovarian cancer, suggesting an autoimmune link to serous cancer development.

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Abstract

Infertility is a risk factor for ovarian cancer (OvCa). The goal was to determine if antibodies to selenium-binding protein 1 (SBP1), an autoantibody we identified in patients with premature ovarian failure (POF), occurs in both infertility and OvCa patients, and thus could be associated with preneoplasia. Anti-SBP1 was measured by immunoassay against recombinant SBP1, in sera from OvCa (n = 41), infertility (n = 92) and control (n = 87) patients. Infertility causes were POF, unexplained, irregular ovulation or endometriosis. The percent of anti-SBP1-positive sera was higher in POF (P = 0.02), irregular ovulation (P = 0.001), unexplained causes (P = 0.02), late (III-IV)-stage OvCa (P = 0.02) but was not significant in endometriosis, benign ovarian tumors/cysts, early stage (I-II) OvCa or uterine cancer compared to healthy controls. Anti-SBP1 was significantly higher in women with serous (P = 0.04) but not non-serous (P = 0.33) OvCa compared to controls. Also, we determined if anti-SBP1 was associated with CA125 or anti-TP53, markers often studied in OvCa. Anti-TP53 and CA125 were measured by established immunoassays. The ability of anti-SBP1 alone to discriminate infertility or OvCa from controls or when combined with anti-TP53 and CA125, to identify OvCa was evaluated by comparing the area under the curve (AUC) in ROC analysis. Anti-SBP1 alone discriminated infertility (AUC = 0.7; P = 0.001) or OvCa (AUC = 0.67; P = 0.03) from controls. The sensitivity and specificity of OvCa identification was increased by combining CA125, anti-TP53 and anti-SBP1 (AUC = 0.96). Therefore, anti-SBP1 occurs in infertile women with POF, ovulatory disturbances or unexplained infertility and in serous OvCa. This suggests an autoimmune process is associated with the development of serous OvCa.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Autoantibodies Biomarkers, Tumor Cystadenocarcinoma, Serous Endometriosis Infertility, Female Ovarian Neoplasms Primary Ovarian Insufficiency Selenium-Binding Proteins Adolescent Adult Aged Aged, 80 and over Autoantibodies Autoantibodies Biomarkers, Tumor Case-Control Studies Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Endometriosis Endometriosis

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