Combinatory effects of current regimens and Guizhi Fuling Wan on the development of endometriosis

Chih-Chen Chen, Chihchen Chen, Chun-Yen Huang, Chun‐Yen Huang, Li‐Yen Shiu, Li-Yen Shiu, Ya-Chun Yu, Jui-Chi Lai, Chi‐Chang Chang, Chi-Chang Chang, Chi‐Feng Fu, Chi-Feng Fu, S Joseph Huang
Taiwanese journal of obstetrics & gynecology · 2022 · vol. 61(1) , pp. 70–74 · doi:10.1016/j.tjog.2021.11.013 · PMID:35181049 · W4213128113
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study found that Guizhi Fuling Wan inhibits endometriosis development in mice, but combining it with western therapies may reduce the individual efficacy of each agent.

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Abstract

OBJECTIVE: Endometriosis, defined as the growth of endometrial glands and stromal cells in a heterotopic location under the cyclic influence of ovarian hormones, is a common gynecological disorder manifested by chronic pelvic pain and infertility. In traditional Chinese medicine, endometriosis is characterized by stagnation of vital energy (qi) and blood stasis. Guizhi Fuling Wan (GFW) was first described in Chinese canonical medicine to treat disorders associated with stagnation of qi and blood stasis, including endometriosis. Therefore, the current study aimed to test the effects of combining GFW with western medicine on the suppression of endometriosis. MATERIALS AND METHODS: Endometriosis was generated by suturing endometrial tissue on the peritoneal wall of C57BL/6JNarl mice. The mice were subsequently treated with either GFW or current hormonal therapies or in combination for 28 days. RESULTS: Endometriosis development was inhibited by GFW, Gestrinone, Visanne, GFW + Gestrinone or GFW + medroxyprogesterone acetate (MPA). The expression of intercellular adhesion molecule 1 (ICAM-1) was inhibited by GFW, Gestrinone, MPA, Visanne, GFW + Gestrinone, GFW + MPA and GFW + Visanne. Vascular endothelial growth factor (VEGF) expression was inhibited by GFW, Gestrinone, Visanne, GFW + Gestrinone and GFW + MPA. Both ICAM-1- and VEGF-reducing effects of GFW were attenuated by western medicines. Administration of GFW, MPA, Visanne, GFW + MPA and GFW + Visanne also correspondingly reduced macrophage population in peritoneal fluid. GFW, MPA, Visanne, GFW + MPA and GFW + Visanne enhanced B-cell population in peritoneal fluid. CONCLUSION: The current study reveals the therapeutic effects of GFW on endometriosis. However, the combination of GFW and current hormonal therapies potentially impedes the efficacy of each individual agent in treating endometriosis.

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Condition tags

mesh:D004715endometriosischronic_pelvic_paininfertility

MeSH descriptors

Drugs, Chinese Herbal Endometriosis Gestrinone Intercellular Adhesion Molecule-1 Medroxyprogesterone Acetate Vascular Endothelial Growth Factor A Animals Drugs, Chinese Herbal Endometriosis Female Gestrinone Intercellular Adhesion Molecule-1 Medroxyprogesterone Acetate Mice Mice, Inbred C57BL Vascular Endothelial Growth Factor A

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