Increased chemotactic activity of peritoneal fluid in patients with endometriosis
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Peritoneal fluid from endometriosis patients exhibited increased chemotactic activity compared to controls, indicating a potential role for chemoattractants in the pathogenesis of the disease.
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Abstract
ObjectiveOur purpose was to investigate the ability of the peritoneal fluid of patients with endometriosis to induce chemotaxis of neutrophils and macrophages.Study designPeritoneal fluid samples of patients with endometriosis (n = 20), normal fertile controls (n = 12), or patients with medical suppression (n = 8) were evaluated for chemotactic activity. Results of chemotactic activity were analyzed by analysis of variance.ResultsPeritoneal fluid of patients with endometriosis demonstrated a significantly higher chemotactic activity than that of patients without endometriosis or with medical suppression. Patients who had received medical treatment had the lowest chemotactic activity. (p < 0.001 for endometriosis vs control or treatment patients, p = 0.005 for control group vs treatment group).ConclusionsPatients with endometriosis have a higher chemotactic activity in their peritoneal fluid; prior medical treatment significantly reduces this activity. This chemotactic factor has an estimated weight of 20 kd. The nature and source of this chemotactic factor remains to be determined.
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Cited by (41)
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- Combinatory effects of current regimens and Guizhi Fuling Wan on the development of endometriosis 2022
- Neutrophils 2021
- Peritoneal macrophages - the key link in development, progression and mantaining of endometriotic lesions and formation of endometriosis-associated infertility 2019
- The Impact of Endometriosis on Fertility 2015
- Pathogenesis of Endometriosis: Roles of Retinoids and Inflammatory Pathways 2015
- Aromatase and endometriosis: estrogens play a role 2014
- Eutopic Endometrium in Women with Endometriosis: Ground Zero for the Study of Implantation Defects 2013
- Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis 2013
- A tumor necrosis factor-α inhibitor reduces the embryotoxic effects of endometriotic peritoneal fluid 2013
- Peritoneal fluid from endometriosis patients switches differentiation of monocytes from dendritic cells to macrophages 2007
- A baboon model for endometriosis: implications for fertility 2006
- Leflunomide—an Immunomodulator—Induces Regression of Endometrial Explants in a Rat Model of Endometriosis 2006
- Effects of peritoneal fluid from endometriosis patients on the release of vascular endothelial growth factor by neutrophils and monocytes 2006
- Endometriosis is associated with alterations in the relative abundance of proteins and IL-10 in the peritoneal fluid 2003
- Uterine Chemokines in Reproductive Physiology and Pathology 2002
- Molecular mechanisms contributing to the pathogenesis of endometriosis 2002
- Signal transduction pathways involved in macrophage migration induced by peritoneal fluid chemotactic factors in stages I and II endometriosis 2002
- Behaviour of Cytokine Levels in Serum and Peritoneal Fluid of Women with Endometriosis 2002
- Modulation of neutrophil apoptosis by plasma and peritoneal fluid from patients with advanced endometriosis 2002
- Expression of matrix metalloproteinases in ovarian endometriomas: immunohistochemical study and enzyme immunoassay 2002
- The fallopian tube and reproductive health 1999
- Chemokines and human reproduction 1999
- Pathogenesis of Endometriosis: The Role of Peritoneal Fluid 1999
- Macrophage Scavenger Receptor(s) and Oxidatively Modified Proteins in Endometriosis 1998
- Endometriotic disease: the role of peritoneal fluid 1998
- Lysophosphatidyl Choline, a Chemotactic Factor for Monocytes/T-Lymphocytes Is Elevated in Endometriosis 1998
- Immunolocalization and Regulation of the Chemokine RANTES in Human Endometrial and Endometriosis Tissues and Cells<sup>1</sup> 1997
- Angiogenesis and Macrophage Activation in Endometriosis 1997
- Monocyte chemotactic protein-l concentration of in in peritoneal fluid women with endometriosis and its modulation mesothelial cells* 1997
- Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells 1997
- Increased expression of complement component 3 in human ectopic endometrium compared with the matched eutopic endometrium 1997
- BASIC RESEARCH IN ENDOMETRIOSIS 1997
- Chemotaxis of macrophages by a peritoneal fluid protein in women with endometriosis 1997
- Growth-regulated α expression in the peritoneal environment with endometriosis 1996
- Increased monocyte chemotactic protein-1 level and activity in the peripheral blood of women with endometriosis 1996
- Peritoneal Growth Factors and Endometriosis 1996
- The peritoneal environment in endometriosis 1996
- Cytokine-induced secretion of monocyte chemotactic protein-1 by human endometriotic cells in culture 1995
- Immunohistochemical localization of granulocyte-macrophage colony-stimulating factor in matched endometriosis and endometrial tissues 1994
- Inflammatory changes of the endometrium in patients with minimal-to-moderate endometriosis 1994
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