Inflammatory changes of the endometrium in patients with minimal-to-moderate endometriosis

M C Leiva, Leiva MC, María C. Leiva, L A Hasty, Lisa A. Hasty, Hasty LA, C. Richard Lyttle, Lyttle CR, C R Lyttle
Fertility and sterility · 1994 · vol. 62(5) , pp. 967–972 · doi:10.1016/s0015-0282(16)57059-9 · PMID:7926143 · W2415641125
article OA: closed CC0 ⤵ 27 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study investigated inflammatory changes in the endometrium of patients diagnosed with minimal-to-moderate endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo investigate the endometrium of normal patients for chemotactic activity to neutrophils and macrophages and compare these findings with those of patients with endometriosis.Study designEndometrial biopsies from patients with and without endometriosis were analyzed for chemotactic activity throughout the menstrual cycle. Glands and stroma of luteal samples were isolated to determine the source of this activity. Infiltrating cells to the endometrium were identified by immunohistochemistry with the use of the monoclonal antibody OKM1.ResultsLuteal endometrial samples from normal patients had higher chemotactic activity than samples from the proliferative phase; this was true for both cells types studied: macrophages, 84 versus 10 and neutrophils, 74 versus 11. Patients with endometriosis had high chemotactic activity in both proliferative and luteal biopsies: macrophages, 73 +/- 9 versus 78 +/- 1 and neutrophils, 41 +/- 18 versus 63 +/- 26. Stromal cells from luteal biopsies demonstrated a higher chemotactic activity than the epithelial component. Immunohistochemistry staining identified the infiltrating cells as macrophages.ConclusionsExtracts from endometrium of normal patients contain chemotactic activity for neutrophils and macrophages; this activity is higher in the secretory phase of the cycle. Endometriosis patients had high chemotactic activity throughout the menstrual cycle. Separation of the endometrial tissue into stroma and the glandular epithelium indicated that the stromal cells are the source of this factor.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Chemotaxis Endometriosis Endometrium Antibodies, Monoclonal Biopsy Endometriosis Endometrium Female Humans Immunohistochemistry Luteal Phase Luteal Phase Macrophages Macrophages Menstrual Cycle Menstrual Cycle Neutrophils Neutrophils Tumor Cells, Cultured

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (27)

Source provenance

europepmc
last seen: 2026-08-15T06:15:18.721777+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:11:24.284338+00:00
License: CC0 · commercial use OK