Increased secretion of hepatocyte growth factor by eutopic endometrial stromal cells in women with endometriosis

Junichi Sugawara, Sugawara J, J Sugawara, Fukaya T, T Fukaya, Takao Fukaya, T Murakami, Murakami T, Takashi Murakami, Yoshida H, Hidemune Yoshida, H Yoshida, A Yajima, Yajima A, Akira Yajima
Fertility and Sterility · 1997 · vol. 68(3) , pp. 468–472 · doi:10.1016/s0015-0282(97)00226-4 · PMID:9314916 · W2047719639
article OA: closed CC0 ⤵ 43 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

Endometrial stromal cells from women with endometriosis were found to secrete higher levels of hepatocyte growth factor compared to those without the condition.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveWe evaluated the secretion of hepatocyte growth factor by eutopic endometrial stromal cells in vitro.DesignEutopic endometrial stromal cells were isolated and the culture supernatants were collected after 48 hours of incubation. The secretion of hepatocyte growth factor was analyzed by ELISA.SettingDepartment of Obstetrics and Gynecology of Tohoku University Hospital.Patient(s)Specimens of endometrium in the proliferative phase were excised from 11 patients who were undergoing laparoscopy for infertility. Six of the patients had endometriosis and five did not. None of the patients had received hormonal treatment before surgery.Result(s)Hepatocyte growth factor secretion was found to be increased significantly in cultured endometrial stromal cells from the infertile patients with endometriosis compared with those without endometriosis.Conclusion(s)The secretion of hepatocyte growth factor was up-regulated in eutopic endometrial stromal cells from patients with endometriosis. An increase in hepatocyte growth factor production may be characteristic of endometriosis and may be involved in the pathophysiology of this disease.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Hepatocyte Growth Factor Adult Cells, Cultured Endometriosis Endometriosis Endometrium Endometrium Factor VIII Factor VIII Female Hepatocyte Growth Factor Humans Leukocyte Common Antigens Leukocyte Common Antigens Stromal Cells Stromal Cells

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (31)

Cited by (44)

Source provenance

europepmc
last seen: 2026-07-26T06:08:39.051465+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:10:46.468712+00:00
unpaywall
last seen: 2026-07-26T06:48:27.953686+00:00
License: CC0 · commercial use OK