Increased secretion of hepatocyte growth factor by eutopic endometrial stromal cells in women with endometriosis

Junichi Sugawara, Sugawara J, J Sugawara, Fukaya T, T. Fukaya, Takao Fukaya, T Murakami, Murakami T, Takashi Murakami, Yoshida H, Hidemune Yoshida, H Yoshida, A Yajima, Yajima A, Akira Yajima
Fertility and sterility · 1997 · vol. 68(3) , pp. 468–472 · doi:10.1016/s0015-0282(97)00226-4 · PMID:9314916 · W2047719639
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Endometrial stromal cells from women with endometriosis were found to secrete higher levels of hepatocyte growth factor compared to those without the condition.

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Abstract

OBJECTIVE: We evaluated the secretion of hepatocyte growth factor by eutopic endometrial stromal cells in vitro. DESIGN: Eutopic endometrial stromal cells were isolated and the culture supernatants were collected after 48 hours of incubation. The secretion of hepatocyte growth factor was analyzed by ELISA. SETTING: Department of Obstetrics and Gynecology of Tohoku University Hospital. PATIENT(S): Specimens of endometrium in the proliferative phase were excised from 11 patients who were undergoing laparoscopy for infertility. Six of the patients had endometriosis and five did not. None of the patients had received hormonal treatment before surgery. RESULT(S): Hepatocyte growth factor secretion was found to be increased significantly in cultured endometrial stromal cells from the infertile patients with endometriosis compared with those without endometriosis. CONCLUSION(S): The secretion of hepatocyte growth factor was up-regulated in eutopic endometrial stromal cells from patients with endometriosis. An increase in hepatocyte growth factor production may be characteristic of endometriosis and may be involved in the pathophysiology of this disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Hepatocyte Growth Factor Adult Adult Cells, Cultured Cells, Cultured Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Factor VIII Factor VIII Factor VIII Female Female Hepatocyte Growth Factor Hepatocyte Growth Factor

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (31)

Cited by (43)

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