Hepatocyte growth factor concentrations are elevated in peritoneal fluid of women with endometriosis

Y Osuga, Yutaka Osuga, Osamu Tsutsumi, O Tsutsumi, R Okagaki, Y Takai, Yasushi Takai, Akihisa Fujimoto, A Fujimoto, A Suenaga, Akihiko Suenaga, M Maruyama, Masashi Maruyama, M Momoeda, Mikio Momoeda, T Yano, Y Taketani
Human Reproduction · 1999 · vol. 14(6) , pp. 1611–1613 · doi:10.1093/humrep/14.6.1611 · PMID:10357985 · W2099195704
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Abstract

The concentrations of hepatocyte growth factor (HGF) in peritoneal fluid (PF) from women with endometriosis (n = 36) and without endometriosis (n = 40) were measured. All of the PF samples examined contained detectable concentrations of HGF. The HGF concentrations in PF from women with stage III/IV endometriosis (0.906 ng/ml, 0. 561-1.185; median, interquartile range) were significantly higher (P < 0.0001) than those from women without endometriosis (0.315 ng/ml, 0.251-0.472). The HGF concentrations from women with stage I/II endometriosis (0.417 ng/ml, 0.310-1.023) appeared to be intermediate. There were no apparent variations detected among the HGF concentrations in women in the follicular or luteal phases regardless of the presence of endometriosis. Interestingly, HGF concentrations in PF from women on gonadotrophin releasing hormone analogues, independent of the presence of endometriosis, were comparable with those from untreated women. Given the known mitogenic property of HGF in human endometrial cells, these results suggest that HGF might play a role in the progression of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Hepatocyte Growth Factor Adult Ascitic Fluid Endometriosis Endometriosis Female Follicular Phase Follicular Phase Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Hepatocyte Growth Factor Humans Luteal Phase Luteal Phase

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