Serum adiponectin concentrations are decreased in women with endometriosis

Yuri Takemura, Yutaka Osuga, Miyuki Harada, Tetsuya Hirata, Kaori Koga, Chieko Morimoto, Yasushi Hirota, Osamu Yoshino, Tetsu Yano, Yuji Taketani
Human Reproduction · 2005 · vol. 20(12) , pp. 3510–3513 · doi:10.1093/humrep/dei233 · PMID:16055459 · W2103534537
article OA: bronze CC0 ⤵ 25 in-corpus citations
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Abstract

BACKGROUND: Adiponectin is a pleiotropic cytokine originally discovered as an adipocyte-specific gene product. Serum adiponectin concentrations have been reported to be low in women with endometrial cancer, breast cancer and uterine leiomyoma, suggesting possible involvement of adiponectin in these estrogen-related diseases. We thus addressed the relevance of adiponectin to endometriosis, an estrogen-dependent disease, in the present study. METHODS: Women with (n = 48) and without (n = 30) endometriosis undergoing laparoscopy were recruited in this study. Blood samples were collected, and serum adiponectin concentrations were measured using a specific enzyme-linked immunosorbent assay. The relationship between laparoscopic findings and serum adiponectin concentrations was analysed. RESULTS: The adiponectin concentrations in the serum of the women with endometriosis (median, 13.1 microg/ml; interquartile range, 10.2 - 16.7) were significantly lower than those of the women without endometriosis (15.9 microg/ml, 13.5 - 19.5; P = 0.008). A significant negative correlation was found between serum adiponectin concentrations and both endometriosis scores (R = - 0.307, P = 0.006) and adhesion scores (R = - 0.254, P = 0.026) of the revised American Society for Reproductive Medicine classification of endometriosis. CONCLUSIONS: The present findings suggest that adiponectin is implicated in the pathophysiology of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Adiponectin Endometriosis Endometriosis Gene Expression Regulation Adiponectin Adiponectin Adult Case-Control Studies Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Laparoscopy Models, Statistical

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