Serum YKL-40 levels as a novel marker of inflammation in patients with endometriosis

Ülkü Mete Ural, Ural UM, U Mete Ural, Yücel Tekìn, Tekin YB, Y Bayoğlu Tekin, Cüre M, M.C. Cure, M Cüre, F. Kir Şahin Şahin, F Kir Şahin, Şahin FK
Clinical and experimental obstetrics & gynecology · 2015 · vol. 42(4) , pp. 495–497 · doi:10.12891/ceog1882.2015 · PMID:26411218 · W2316791087
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Serum YKL-40 levels were significantly elevated in patients with endometriosis compared to healthy controls, suggesting its potential as a novel biomarker.

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This cross-sectional study compared serum YKL-40 concentrations between 33 endometriosis patients and 30 age-matched healthy controls recruited from a tertiary care center. Serum YKL-40 was measured using an ELISA kit, and demographics and YKL-40 levels were recorded. The authors found higher mean serum YKL-40 levels in the endometriosis group than in controls (106.0 ± 15.9 vs 52.2 ± 7.0; p = 0.003). The paper’s limitation is that the design does not establish causality, and it does not evaluate diagnostic performance or longitudinal changes; it remains based on this single assessment. This paper is centrally about endometriosis — it evaluates serum YKL-40 as an inflammation-related biomarker in patients with endometriosis.

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Abstract

PURPOSE: To establish serum YKL-40 concentrations in patients with endometriosis compared to age-matched healthy subjects. MATERIALS AND METHODS: This was a cross-sectional clinical study conducted in a tertiary care center. Demographics and serum YKL levels were determined and noted in a total of 63 cases (33 endometriosis patients, 30 healthy controls). Measurement of YKL-40 levels was made using a YKL-40 enzyme-linked immunosorbent assay (ELISA) kit according to the manufacturer's protocol. RESULTS: The mean serum YKL-40 levels of the patient group was 106.0 +/- 15.9 (range 23.44 to 382.55) years, while the mean serum YKL-40 levels of the controls was 52.2 +/- 7.0 (range 22.35 to 160.0) years (p = 0.003). CONCLUSIONS: This is the first study evaluating serum YKL-40 levels in endometriosis. The present results indicate that YKL-40 levels were increased in patients with endometriosis compared to controls. The authors propose that circulating YKL-40 levels could be a novel biomarker for diagnosis and follow-up of endometriosis.
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Abstract

Purpose: To establish serum YKL-40 concentrations in patients with endometriosis compared to age-matched healthy subjects. Materials and Methods: This was a cross-sectional clinical study conducted in a tertiary care center. Demographics and serum YKL levels were determined and noted in a total of 63 cases (33 endometriosis patients, 30 healthy controls). Measurement of YKL-40 levels was made using a YKL-40 enzyme-linked immunosorbent assay (ELISA) kit according to the manufacturer’s protocol. Results: The mean serum YKL-40 levels of the patient group was 106.0 ± 15.9 (range 23.44 to 382.55) years, while the mean serum YKL-40 levels of the controls was 52.2 ± 7.0 (range 22.35 to 160.0) years (p = 0.003). Conclusions: This is the first study evaluating serum YKL-40 levels in endometriosis. The present results indicate that YKL-40 levels were increased in patients with endometriosis compared to controls. The authors propose that circulating YKL-40 levels could be a novel biomarker for diagnosis and follow-up of endometriosis.

Keywords

- Endometriosis - Serum - YKL-40 levels - Marker

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Condition tags

endometriosis

MeSH descriptors

Adipokines Biomarkers Endometriosis Lectins Adipokines Adipokines Adult Biomarkers Case-Control Studies Chitinase-3-Like Protein 1 Cross-Sectional Studies Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Lectins Lectins

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