Elevated Levels of Monocyte Chemotactic Protein-1 in the Follicular Fluid Reveals Different Populations among Women with Severe Endometriosis

Pierre‐Emmanuel Bouet, Pierre-Emmanuel Bouet, Juan-Manuel Chao de la Barca, Lisa Boucret, Philippe Descamps, Guillaume Legendre, Hady El Hachem, Simon Blanchard, Pascale Jeannin, Pascal Reynier, Pascale May‐Panloup
Journal of clinical medicine · 2020 · vol. 9(5) , pp. 1306 · doi:10.3390/jcm9051306 · PMID:32370059 · PMC7291127 · W3020884758
article OA: gold CC0 ⤵ 11 in-corpus citations
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This study found elevated monocyte chemoattractant protein 1 (MCP-1) in follicular fluid from women with severe endometriosis, identifying a subgroup with altered cytokine profiles and fewer oocytes recovered.

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Abstract

To determine if a modification of the cytokine profile occurs in the follicular fluid (FF) of women with endometriosis undergoing in vitro fertilization (IVF), we performed a prospective observational study from January 2018 to February 2019. In total, 87 women undergoing IVF were included: 43 for severe endometriosis-related infertility and 40 controls with other causes of infertility. The cytokine profile of the FF was determined by multiplex fluorescent-bead-based technology allowing the measurement of 59 cytokines. Monocyte Chemoattractant Protein 1 (MCP-1) was the only variable retained in the multivariate analysis. We identified two subgroups of patients in the endometriosis group: MCP-1-low group (n = 23), which had FF MCP-1 levels comparable to the control group, and MCP-1-high (n = 20), which had significantly higher FF levels. Only patients in the MCP-1-high group had a significantly altered cytokine profile in the FF, and had a significantly higher serum estradiol level (p = 0.002) and a significantly lower number of oocytes recovered (p = 0.01) compared to the MCP-1-low and the control group. Our study has shown an alteration of the oocyte microenvironment in women with endometriosis associated with high follicular fluid levels of MCP-1, allowing the identification of a subgroup of endometriosis patients with a potentially worse prognosis.

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endometriosisinfertility

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