Ovarian suppression treatment prior to in‐vitro fertilization and embryo transfer in Chinese women with stage III or IV endometriosis

Caihong Ma, Jie Qiao, Ping Liu, Guian Chen
International Journal of Gynecology & Obstetrics · 2007 · vol. 100(2) , pp. 167–170 · doi:10.1016/j.ijgo.2007.08.021 · PMID:18029283 · W2081895812
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Two-month GnRH agonist ovarian suppression prior to IVF significantly increased implantation rates in Chinese women with stage III/IV endometriosis compared to standard protocols.

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Abstract

OBJECTIVE: To evaluate the efficacy of a 2-month treatment with a gonadotropin-releasing hormone (GnRH) agonist prior to in-vitro fertilization in Chinese women with moderate or severe endometriosis. METHODS: A study of 162 women surgically diagnosed as having moderate or severe endometriosis. Pituitary down-regulation was achieved with injections of a GnRH agonist prior to the IVF procedures either for 7 to 10 days in the mid-luteal phase (group 1 [standard protocol], 97 cycles in total), or for 2 months (group 2, 55 cycles), or 3 months (group 3, 75 cycles). RESULTS: Women pretreated with a GnRH agonist for 2 or 3 months required significantly higher doses of gonadotropin for ovarian stimulation (P<0.001), and for a longer time, than those treated with the standard long protocol (P<0.05). The number of oocytes and good embryos was lower in group 3 than in groups 1 or 2 (P<0.05). The implantation rate was significantly higher in group 2 than in group 1 (P<0.02). CONCLUSION: A 2-month treatment with a GnRH agonist prior to IVF produced a trend toward an increase in the implantation rate in a group of Chinese women with stages III and IV endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Embryo Transfer Endometriosis Gonadotropin-Releasing Hormone Luteolytic Agents Triptorelin Pamoate Adult Cohort Studies Dose-Response Relationship, Drug Embryo Transfer Endometriosis Female Fertilization in Vitro Fertilization in Vitro Gonadotropin-Releasing Hormone Humans Luteolytic Agents Ovary Ovary Ovulation Induction Ovulation Induction

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