Ovarian suppression treatment prior to in-vitro fertilization and embryo transfer in Chinese women with stage III or IV endometriosis

Ma C, Caihong Ma, Qiao J, Jie Qiao, Liu P, Ping Liu, Guian Chen, Chen G
International Journal of Gynecology & Obstetrics · 2007 · vol. 100(2) , pp. 167–170 · doi:10.1016/j.ijgo.2007.08.021 · PMID:18029283 · W2081895812
Non-randomised trial OA: closed CC0 ⤵ 30 in-corpus citations
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Two-month GnRH agonist ovarian suppression prior to IVF significantly increased implantation rates in Chinese women with stage III/IV endometriosis compared to standard protocols.

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Abstract

OBJECTIVE: To evaluate the efficacy of a 2-month treatment with a gonadotropin-releasing hormone (GnRH) agonist prior to in-vitro fertilization in Chinese women with moderate or severe endometriosis. METHODS: A study of 162 women surgically diagnosed as having moderate or severe endometriosis. Pituitary down-regulation was achieved with injections of a GnRH agonist prior to the IVF procedures either for 7 to 10 days in the mid-luteal phase (group 1 [standard protocol], 97 cycles in total), or for 2 months (group 2, 55 cycles), or 3 months (group 3, 75 cycles). RESULTS: Women pretreated with a GnRH agonist for 2 or 3 months required significantly higher doses of gonadotropin for ovarian stimulation (P<0.001), and for a longer time, than those treated with the standard long protocol (P<0.05). The number of oocytes and good embryos was lower in group 3 than in groups 1 or 2 (P<0.05). The implantation rate was significantly higher in group 2 than in group 1 (P<0.02). CONCLUSION: A 2-month treatment with a GnRH agonist prior to IVF produced a trend toward an increase in the implantation rate in a group of Chinese women with stages III and IV endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Embryo Transfer Endometriosis Gonadotropin-Releasing Hormone Luteolytic Agents Triptorelin Pamoate Adult Adult Cohort Studies Cohort Studies Dose-Response Relationship, Drug Dose-Response Relationship, Drug Embryo Transfer Embryo Transfer Endometriosis Endometriosis Female Female Fertilization in Vitro Fertilization in Vitro Fertilization in Vitro

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (9)

Cited by (30)

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