Serum tumor necrosis factor-α, interleukin-6, monocyte chemotactic protein-1 and paraoxonase-1 profiles in women with endometriosis, pcos, or unexplained infertility

Abdelmoneim I. Younis, Abdelmoneim Younis, Kristina Hawkins, Kristina C. Hawkins, Halleh Mahini, William Butler, William J. Butler, Mahdi Garelnabi
Journal of assisted reproduction and genetics · 2014 · vol. 31(11) , pp. 1445–1451 · doi:10.1007/s10815-014-0237-9 · PMID:25186501 · PMC4389928 · W2043053655
article OA: bronze CC0 ⤵ 17 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This study examined serum levels of TNF-α, IL-6, MCP-1, and PON-1 in women with endometriosis, PCOS, or unexplained infertility during fertility treatments.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This study measured serum TNF-α, IL-6, MCP-1, and paraoxonase-1 (PON-1) at baseline (day 3) and at the end of FSH stimulation (E2 peak) in 36 women with endometriosis, PCOS, or unexplained infertility undergoing IVF or IUI. Peak IL-6, MCP-1, and PON-1 were positively correlated with E2 peak levels, while TNF-α showed an inverse correlation with estradiol and was lower among those who became pregnant; mean TNF-α was higher in the unexplained infertility group. IL-6 and MCP-1 were higher in women with PCOS than in the endometriosis and unexplained groups, and the authors reported no differences among groups for several baseline measures and PON-1, nor a relationship between PON-1 and endometriosis/PCOS/unexplained infertility. The paper’s limitation, as stated in the abstract, is that it found no evidence of a relationship between circulating cytokines and mild endometriosis. Relevance to endometriosis: endometriosis was included as one of the comparative infertility groups, and the authors specifically report no evidence of a relationship between circulating cytokines with mild endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Aryldialkylphosphatase Chemokine CCL2 Endometriosis Infertility, Female Interleukin-6 Polycystic Ovary Syndrome Tumor Necrosis Factor-alpha Adult Aryldialkylphosphatase Biomarkers Biomarkers Chemokine CCL2 Endometriosis Female Gonadotropins Gonadotropins Humans Infertility, Female Interleukin-6 Ovulation Induction

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