There is no relationship between Paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study

Felipe Barca Bragatto, Caio Parente Barbosa, Denise Maria Christofolini, Carla Peluso, Aline Amaro dos Santos, Fernanda Abani Mafra, Fernanda Mafra, Viviane Cavalcanti, Sonia Hix, Sônia Hix, Bianca Bianco
Reproductive health · 2013 · vol. 10(1) , pp. 32 · doi:10.1186/1742-4755-10-32 · PMID:23799909 · W2136372232
article OA: gold CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This observational study found no significant difference in serum paraoxonase activity between women with minimal/mild and moderate/severe endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This observational study measured serum paraoxonase-1 (PON1) activity (paraoxonase and arylesterase/phenylacetate activities) in 80 infertile women with laparoscopically and histologically confirmed endometriosis, stratified into minimal/mild (stages I–II) versus moderate/severe (stages III–IV) disease using the ASRM classification. Key findings were that paraoxonase activity and arylesterase activity did not differ between the two stage groups, and no association with disease stage was identified. A limitation explicitly noted by the study is that it focused on enzymatic activity differences across stages in a selected infertile population while excluding factors like obesity, smoking, and partner male-factor infertility, which may restrict generalizability. This paper is centrally about endometriosis — it tests whether PON1 serum antioxidant activity varies with endometriosis stage and reports no relationship.

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Abstract

BACKGROUND: Endometriosis is a chronic condition whose pathophysiology is unknown, but there is evidence suggesting a link with oxidative stress. Paraoxonase is a serum enzyme which circulates associated with high-density lipoprotein (HDL). It acts protecting HDL and LDL of lipid peroxidation. We aimed to compare the serum levels of PON-1 activity in women with endometriosis in different stages of the disease (minimal/mild and moderate/severe). METHODS: 80 infertile women with endometriosis diagnosed by laparoscopy/laparotomy with histologic confirmation of the disease were divided according to the American Society for Reproductive Medicine classification in minimal/mild (n = 33) and moderate/severe (n = 47) cases. Paraoxonase activity and arilesterase activity were measured by spectrophotometry. Body mass index and fasting glucose levels were also determined. RESULTS: The paraoxonase activity were 191.29 ± 22.41 U/l in women with minimal/mild endometriosis and 224.85 ± 21.50 U/l in women with moderate/severe disease (P = 0.274). Considering arilesterase level, the results showed 89.82 ± 4.61 U/l in women with minimal/mild endometriosis and 90.78 ± 3.43 U/l in moderate/severe disease (P = 0.888). CONCLUSIONS: Evidence of lower paraoxonase activity in women with endometriosis was not found in this study. Besides, no difference was found considering minimal/mild or moderate/severe endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Aryldialkylphosphatase Endometriosis Adult Aryldialkylphosphatase Endometriosis Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Oxidative Stress

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