Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility

Jørgensen H, Hilde Jørgensen, Abby S. Hill, Michael T. Beste, Beste MT, Kumar MP, Manu P. Kumar, Chiswick E, Evan Chiswick, Evan L. Chiswick, Peter Fedorcsak, Péter Fedorcsák, Keith B Isaacson, Isaacson KB, Keith Isaacson, Lauffenburger DA, Douglas A. Lauffenburger, Linda G. Griffith, Erik Qvigstad, Qvigstad E
Fertility and sterility · 2017 · vol. 107(5) , pp. 1191–1199.e2 · doi:10.1016/j.fertnstert.2017.03.013 · PMID:28433374 · W2605749751
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This study identified specific cytokine profiles within peritoneal fluid that are associated with endometriosis in infertile patients.

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This cross-sectional study analyzed peritoneal fluid cytokine profiles in 107 women undergoing laparoscopy for infertility to identify immune differences associated with endometriosis. Researchers measured 48 cytokines and found that levels of SCGF-β, IL-8, HGF, and MCP-1 were significantly higher, while IL-13 was lower in patients with endometriosis compared to those without. A combination of three specific cytokines successfully predicted the presence of endometriosis with high sensitivity, highlighting distinct inflammatory signatures in affected individuals. This paper is centrally about endometriosis — specifically characterizing peritoneal fluid cytokine profiles in infertile patients to distinguish disease states.

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Abstract

ObjectiveOur aim was to characterize peritoneal cytokine profiles in patients with infertility, with and without endometriosis, to illuminate potential differences in immune profiles that may reflect mechanistic differences between these two patient populations.DesignCross-sectional study.SettingUniversity hospital and research center.Patient(s)Women undergoing laparoscopy for infertility investigation (n = 107).Intervention(s)Peritoneal fluid was collected during surgery. Clinical characteristics were registered preoperatively.Main outcome measure(s)We determined the concentration of 48 different cytokines from the peritoneal fluid with multiplex immunoassays. Associations between cytokines and clinical findings were assessed with logistic regression and partial least squares discriminant analyses (PLS-DA).Result(s)Concentrations of SCGF-β, IL-8, HGF, and MCP-1 were significantly higher, while IL-13 was significantly lower in the endometriosis group compared with the group without endometriosis. Multiple stepwise logistic regression identified a combination of SCGF-β, IL-13, and G-CSF concentrations that predicted the presence of endometriosis with 86% sensitivity and 67% specificity. PLS-DA identified a class of 11 cytokines (SCGF-β, HGF, IL-13, MCP-1, CTACK, MCP-3, M-CSF, LIF, IL-5, IL-9, and IFN-a2) that were more characteristic of endometriosis than nonendometriosis patients.Conclusion(s)By combining univariate and multivariate analyses, profiles of cytokines more likely to be enriched or depleted in infertility patients with endometriosis compared with those without endometriosis were identified. These findings may inform future analyses of pathophysiological mechanisms of endometriosis in infertile patients, including dysregulated Th1/Th2 response and mobilization and proliferation of hematopoietic stem cells.
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Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility Author(s) • • • • • • • • • Jørgensen, Hilde Hill, Abby Beste, Michael T. Kumar, Manu Prajapati Chiswick, Evan Fedorcsak, Peter Isaacson, Keith B. Lauffenburger, Douglas A. Griffith, Linda G. Qvigstad, Erik Date Issued April 2017 Journal Fertility and Sterility Publisher Elsevier BV Citation Jørgensen, Hilde et al. "Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility." Fertility and Sterility, 107, 5 (May 2017): 1191-1199.e2 Version Original manuscript Abstract Objective: Our aim was to characterize peritoneal cytokine profiles in patients with infertility, with and without endometriosis, to illuminate potential differences in immune profiles that may reflect mechanistic differences between these two patient populations. Design: Cross-sectional study. Setting: University hospital and research center. Patient(s): Women undergoing laparoscopy for infertility investigation (n = 107). Intervention(s): Peritoneal fluid was collected during surgery. Clinical characteristics were registered preoperatively. Main Outcome Measure(s): We determined the concentration of 48 different cytokines from the peritoneal fluid with multiplex immunoassays. Associations between cytokines and clinical findings were assessed with logistic regression and partial least squares discriminant analyses (PLS-DA). Result(s): Concentrations of SCGF-β, IL-8, HGF, and MCP-1 were significantly higher, while IL-13 was significantly lower in the endometriosis group compared with the group without endometriosis. Multiple stepwise logistic regression identified a combination of SCGF-β, IL-13, and G-CSF concentrations that predicted the presence of endometriosis with 86% sensitivity and 67% specificity. PLS-DA identified a class of 11 cytokines (SCGF-β, HGF, IL-13, MCP-1, CTACK, MCP-3, M-CSF, LIF, IL-5, IL-9, and IFN-a2) that were more characteristic of endometriosis than nonendometriosis patients. Conclusion(s): By combining univariate and multivariate analyses, profiles of cytokines more likely to be enriched or depleted in infertility patients with endometriosis compared with those without endometriosis were identified. These findings may inform future analyses of pathophysiological mechanisms of endometriosis in infertile patients, including dysregulated Th1/Th2 response and mobilization and proliferation of hematopoietic stem cells. Keyword: Cytokine; endometriosis; infertility; peritoneal fluid; PLS-DA MIT Department Massachusetts Institute of Technology. Center for Gynepathology Research Massachusetts Institute of Technology. Department of Biological Engineering Terms of Use Creative Commons Attribution-NonCommercial-NoDerivs License Persistent DSpace Link DOI of Published Version https://doi.org/10.1016/j.fertnstert.2017.03.013

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Condition tags

endometriosisinfertility

MeSH descriptors

Ascitic Fluid Cytokines Endometriosis Endometriosis Infertility, Female Infertility, Female Adult Ascitic Fluid Biomarkers Biomarkers Comorbidity Cross-Sectional Studies Cytokines Diagnosis, Differential Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female

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