Interleukin-6 in experimental endometriosis

Lim YT, Yong-Taik Lim, Y T Lim, Robert S. Schenken, R S Schenken, Schenken RS
Fertility and sterility · 1993 · vol. 59(4) , pp. 912–916 · doi:10.1016/s0015-0282(16)55881-6 · PMID:8458515 · W2410252455
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This study investigated the role of interleukin-6 in experimental models of endometriosis, finding that it promotes lesion growth and alters immune cell infiltration.

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Abstract

ObjectiveTo measure the concentration of interleukin-6 (IL-6) in peripheral serum and conditioned media (CM) of macrophages collected from the peritoneal cavity in rats before and after surgically inducing endometriosis.DesignAdult female rats (n = 50) underwent autotransplantation of adipose tissue or uterine squares. Peritoneal cavity macrophages were collected at the initial laparotomy. Rats were killed 4 or 8 weeks later, and peripheral serum and peritoneal cavity macrophages were collected. Macrophages were cultured for 48 hours, and the IL-6 concentrations in CM and serum were measured using the B9 hybridoma cell line bioassay.ResultsSerum IL-6 levels were significantly increased at 4 weeks but not at 8 weeks in rats receiving endometrial implants. Interleukin-6 production by macrophages from rats with endometrial implants at 4 or 8 weeks was not significantly different from baseline or from rats receiving adipose tissue implants.ConclusionThe increased serum IL-6 levels at 4 but not 8 weeks after surgical induction of endometriosis suggest that IL-6 may be involved in the initial development of endometriosis in this experimental model.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Interleukin-6 Macrophages Animals Cells, Cultured Endometriosis Endometriosis Female Interleukin-6 Interleukin-6 Interleukin-6 Interleukin-6 Macrophages Peritoneal Cavity Peritoneal Cavity Rats Rats, Sprague-Dawley

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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