Vaginal hyperalgesia in a rat model of endometriosis

Berkley KJ, K. J. Berkley, Karen J. Berkley, A Cason, Angie M. Cason, Cason A, H. B. Jacobs, H Jacobs, Jacobs H, Heather B. Bradshaw, Bradshaw H, H Bradshaw, Wood E, Elizabeth C. Wood, E Wood
Neuroscience letters · 2001 · vol. 306(3) , pp. 185–188 · doi:10.1016/s0304-3940(01)01906-1 · PMID:11406326 · W2115041299
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated vaginal hyperalgesia in a rat model of endometriosis to understand pain mechanisms associated with the condition.

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Abstract

This study examined whether a rat model of surgically-induced endometriosis that reduces fertility also evokes vaginal hyperalgesia along with changes in vaginal compliance. In nine rats trained to escape vaginal distention, percent escape responses to different volumes of vaginal distention were measured for 2.5 months before and after endometriosis or sham surgery. Vaginal pressures were also measured simultaneously to provide an estimate of vaginal compliance. Endometriosis (or sham) was induced by autotransplantation of small pieces of uterus (or fat) on mesenteric cascade arteries, abdomen, and ovary. Escape responses were significantly increased only in rats whose autotransplants had formed cysts. Vaginal pressures, however, remained unchanged. This vaginal hyperalgesia may involve a process of viscero-visceral referred hyperalgesia.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Hyperalgesia Vagina Adipose Tissue Adipose Tissue Animals Catheterization Conditioning, Psychological Cysts Cysts Disease Models, Animal Endometriosis Escape Reaction Female Hyperalgesia Pressure Rats Uterus Uterus Vagina

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References (21)

Cited by (50)

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