Endometrial diseases: a summary of small experimental animal model

Huai Yang, Meng Du, Goh Meei Chyn, Xiaowen Liang, Lingling Lei, Ling-Ling Lei, Zhili Guo, Zhiyi Chen
Biology of reproduction · 2025 · vol. 113(2) , pp. 237–256 · doi:10.1093/biolre/ioaf087 · PMID:40699004 · W4412612784
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This review summarizes small animal models used for endometrial diseases, detailing their methods, applications, challenges, and future prospects to guide appropriate model selection.

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Abstract

Endometrium plays a crucial role in embryonic growth and development. Endometrial-related diseases, such as endometritis, endometriosis, endometrial cancer, and intrauterine adhesions, hurt fertility and women's health. At present, these diseases often lack effective or permanent treatments, necessitating the construction of analogous animal models for research and solution development. To mitigate the waste of time, financial resources, and the potential for excessive harm to animals resulting from the utilization of unsuitable animal models, it is imperative to judiciously select the appropriate models. Given that most laboratories have limited space and equipment, as well as employ a high percentage of small rodents, this review aims to provide a comprehensive summary of the small experimental animals currently used in the establishment of models for endometrial-related diseases, especially for their operational methodologies, applications, challenges associated with the techniques, and prospects for future development.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal Disease Models, Animal

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-30T00:31:16.422117+00:00
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